Study on High Blood Pressure in Children
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Recruiting
Observational Study
Hypertension
Left Ventricular Hypertrophy
Left Ventricular Dysfunction
Left Atrial Dilatation
Left Ventricular Diastolic Dysfunction
Kidney Diseases
Kidney Injury
Kidney Dysfunction
Sodium Urine High
Blood Pressure Disorders
Uric Acid Retention
Angiotensin Hypertension
Autonomic Dysfunction
Autonomic Imbalance
Pediatric Kidney Disease
Pediatric Obesity
Proteinuria
Albuminuria
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 7 – 18
- Sex
- Any
- Study type
- Observational
- Participants needed
- 125 (estimated)
- Sponsor
- Wake Forest University Health Sciences · Other
Who this trial is looking for
This trial is looking for children aged 7 to 18 who have been diagnosed with high blood pressure. Participants will provide blood and urine samples and undergo various tests to help understand hypertension and its effects on the body.
Are You a Good Fit for This Trial?
You may be able to join if
- I am between 7 and 18 years old.
- I have been diagnosed with new primary hypertension.
- I have high blood pressure measurements.
- I can complete the study assessments.
You may not be able to join if
- I am younger than 7 or older than 18 years old.
- I have normal or only elevated blood pressure.
- I have a known secondary cause of high blood pressure.
- I have a serious heart or kidney problem.
- I cannot complete the study assessments.
- I do not speak English or Spanish.
- I am currently pregnant.
- I am a ward of the state.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric hypertension and related target organ injury, including in the heart, kidneys, vasculature, and brain. Recruiting children with a new hypertension diagnosis over a 2-year period fro…
Trial Locations
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Eligibility Criteria
INCLUSION CRITERIA: HYPERTENSION COHORT
* 7-18 years of age at time of enrollment
* Confirmed new diagnosis of primary hypertension: no identifiable secondary cause, referred to hypertension or nephrology clinic
* Age \<13 years: BP ≥95th %ile or ≥130/80 mmHg (whichever is lower)
* Age ≥13 yea…
Contacts