Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Recruiting
Observational Study
Hypertension
Left Ventricular Hypertrophy
Left Ventricular Dysfunction
Left Atrial Dilatation
Left Ventricular Diastolic Dysfunction
Kidney Diseases
Kidney Injury
Kidney Dysfunction
Sodium Urine High
Blood Pressure Disorders
Uric Acid Retention
Angiotensin Hypertension
Autonomic Dysfunction
Autonomic Imbalance
Pediatric Kidney Disease
Pediatric Obesity
Proteinuria
Albuminuria
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 7 – 18
- Sex
- Any
- Study type
- Observational
- Participants needed
- 125 (estimated)
- Sponsor
- Wake Forest University Health Sciences · Other
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About This Trial
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric hypertension and related target organ injury, including in the heart, kidneys, vasculature, and brain. Recruiting children with a new hypertension diagnosis over a 2-year period fro…
Trial Locations
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Eligibility Criteria
INCLUSION CRITERIA: HYPERTENSION COHORT
* 7-18 years of age at time of enrollment
* Confirmed new diagnosis of primary hypertension: no identifiable secondary cause, referred to hypertension or nephrology clinic
* Age \<13 years: BP ≥95th %ile or ≥130/80 mmHg (whichever is lower)
* Age ≥13 yea…
Contacts