No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 99
Sex
Any
Study type
Observational
Participants needed
40 (estimated)
Sponsor
Tufts Medical Center · Other
Who this trial is looking for
This trial is looking for adults who have had COVID-19 and are experiencing ongoing breathing problems or fatigue. Participants will undergo scans to evaluate their lung function and circulation.
Are You a Good Fit for This Trial?
Rules you outAsthmaCOPDHeart failurePulmonary hypertension
You may be able to join if
I am 18 years or older
I had a confirmed case of COVID-19 over 3 months ago
I have normal or mild breathing test results
I have new or worsening fatigue or breathing issues after COVID-19
You may not be able to join if
I had a new COVID-19 infection in the last 3 months
I cannot provide consent or speak English
I am pregnant
I have had a respiratory infection in the last 4 weeks
I have a serious lung or heart condition
I am currently being treated for cancer or have had lung cancer
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Prospective cohort study to evaluate the utility of quantitative CT analysis to assess ventilation and perfusion defects in patients with Post-acute Sequelae of SARS-CoV-2 (PASC) and functional limitations
Trial Locations
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City
State
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Status
Eligibility Criteria
Inclusion Criteria:
* Age ≥ 18
* Self-reported or documented SARS-CoV-2 infection by RT-PCR or Antigen testing \> 3 months ago or no previous history of SARS-CoV-2 infection (control group only)
* Normal or mild abnormalities on baseline Pulmonary Function Tests (PFTs)
* New or worsening symptoms o…
Inclusion Criteria:
* Age ≥ 18
* Self-reported or documented SARS-CoV-2 infection by RT-PCR or Antigen testing \> 3 months ago or no previous history of SARS-CoV-2 infection (control group only)
* Normal or mild abnormalities on baseline Pulmonary Function Tests (PFTs)
* New or worsening symptoms of chronic fatigue, dyspnea or exercise intolerance after COVID-19 with otherwise unclear etiology (PASC group only)
Exclusion Criteria:
* SARS-CoV-2 infection by RT-PCR or Antigen testing within the last 3 months
* Inability to provide consent or non-English speaking
* Pregnancy
* Any respiratory infection in last 4 weeks
* PFT relative contraindications
* History of major cardiovascular, pulmonary, renal, hepatic, autoimmune or neuromuscular disease including asthma, COPD, interstitial lung disease, heart failure, pulmonary arterial hypertension, or prior pulmonary embolism
* Active malignancy undergoing treatment or history of malignancy involving the lung
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