No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
14 – 18
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
60 (estimated)
Sponsor
Children's Hospital Medical Center, Cincinnati · Other
Who this trial is looking for
This trial is looking for teenagers with major depression who are currently hospitalized. Participants will receive a specific treatment called deep Transcranial Magnetic Stimulation (dTMS) in addition to their usual care.
Are You a Good Fit for This Trial?
You may be able to join if
I am aged 14 to 18 years old.
I have been diagnosed with major depressive disorder.
I have moderate to severe depression symptoms.
I can speak and read in English.
I can understand the study's purpose and risks.
I do not need to stop my current treatments.
You may not be able to join if
I have participated in another drug trial in the last three months.
I have a history of epilepsy or have metal implants in my body.
I am currently experiencing severe psychosis.
I am actively suicidal with a plan.
I am a female with a positive pregnancy test.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Evaluate the feasibility, safety, and preliminary efficacy of deep Transcranial Magnetic Stimulation (dTMS) as an adjunctive treatment for adolescents hospitalized with major depressive disorder (MDD).
Trial Locations
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City
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Eligibility Criteria
Inclusion Criteria:
1. Fluent in English and able to volunteer in the informed consent process and provide spontaneous narrative description of key elements, risks, and benefits of the study.
2. Aged 14 years to 18 years, inclusive.
3. Diagnosis of MDD based on psychologist diagnosis and DSM-5-chec…
Inclusion Criteria:
1. Fluent in English and able to volunteer in the informed consent process and provide spontaneous narrative description of key elements, risks, and benefits of the study.
2. Aged 14 years to 18 years, inclusive.
3. Diagnosis of MDD based on psychologist diagnosis and DSM-5-checklist based interview.
4. Symptoms of moderate to severe depression according to Hamilton Depression Rating Scale Score \> 20.
5. Participants are not required to discontinue current interventions
Exclusion Criteria:
1. Participation in an investigational drug trial within the past three months.
2. Contraindications to Transcranial Magnetic Stimulation including, but not limited to, a history of epilepsy, the presence of metallic foreign bodies, or implanted medical devices (e.g. ventriculoperitoneal shunt, pacemaker, medical pump).
3. Actively psychotic (i.e. disorganized, delusional, paranoid, or having hallucinations)
4. Actively suicidal (have a suicidal plan and intent and is on 1:1 close observation)
5. For female subjects of childbearing potential, a positive urine pregnancy test.
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