Insulin Regulation of Lipolysis and Lipolysis Proteins
Recruiting
Early Phase 1
Interventional Study
Obesity
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 55
- Sex
- Any
- Trial phase
- Early Phase 1
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 64 (estimated)
- Sponsor
- Mayo Clinic · Other
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About This Trial
These studies will define the abnormalities in the adipocyte proteins that are involved in the failure of insulin to suppress lipolysis normally in humans with upper body obesity and will help discover the mechanism by which pioglitazone, a medication used to treat type 2 diabetes and improve insulin resistance, improves insulin-regulation of adipocyte fatty acid metabolism.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Men and Women between the ages of 18 and 55.
* Women will be premenopausal
* Non obese adults BMI between 18-25
* Obese BMI 30-38
Exclusion Criteria, Pioglitazone package insert of contraindications for use:
* Initiation in patients with established New York Heart Associatio…
Contacts
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