Pioglitazone for Obesity Treatment

Insulin Regulation of Lipolysis and Lipolysis Proteins

Recruiting Early Phase 1 Interventional Study
Obesity
Healthy Volunteers Welcome You do not need to have the condition being studied to take part.
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Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 55
Sex
Any
Trial phase
Early Phase 1
Study type
Interventional
Purpose
Basic Science
Participants needed
64 (estimated)
Sponsor
Mayo Clinic · Other
Who this trial is looking for

This trial is looking for adults with obesity or healthy weight to understand how a diabetes medication affects fat metabolism. Participants will help researchers learn more about insulin and fat breakdown in the body.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am between 18 and 55 years old.
  • I am a premenopausal woman.
  • I have a BMI between 18 and 25.
  • I have a BMI between 30 and 38.

You may not be able to join if

  • I have severe heart failure.
  • I am allergic to pioglitazone or its ingredients.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.

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About This Trial

These studies will define the abnormalities in the adipocyte proteins that are involved in the failure of insulin to suppress lipolysis normally in humans with upper body obesity and will help discover the mechanism by which pioglitazone, a medication used to treat type 2 diabetes and improve insulin resistance, improves insulin-regulation of adipocyte fatty acid metabolism.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Men and Women between the ages of 18 and 55. * Women will be premenopausal * Non obese adults BMI between 18-25 * Obese BMI 30-38 Exclusion Criteria, Pioglitazone package insert of contraindications for use: * Initiation in patients with established New York Heart Associatio…
Contacts

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