Effects of GLP-1 Agonist in Type 1 and Type 2 Diabetes
The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes
Recruiting
Phase 2
Interventional Study
Type 1 Diabetes
Type 2 Diabetes
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 25 – 70
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 60 (estimated)
- Sponsor
- Mayo Clinic · Other
Who this trial is looking for
This trial is looking for people with type 1 or type 2 diabetes who are treated with insulin. Participants will receive a GLP-1 receptor agonist and their islet GLP-1 levels will be studied.
Are You a Good Fit for This Trial?
You may be able to join if
- I have type 1 or type 2 diabetes
- I am treated with insulin
You may not be able to join if
- I am under 25 or over 70 years old
- My HbA1c is over 10.0%
- I am pregnant or have a positive pregnancy test
- I have had upper abdominal surgery in the past
- I have used GLP-1 receptor agonists in the past year
- I have an active illness or cancer
- I have symptoms of vascular disease
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
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About This Trial
The investigators recently demonstrated that blockade of Glucagon-Like Peptide-1's (GLP-1) receptor (GLP1R) results in changes in islet function without changes in circulating GLP-1. These effects are more pronounced in people with early type 2 diabetes (T2DM) in keeping with increased expression of PC-1/3 and GLP-1 that is observed in diabetic islets. However, its regulation is at present unknown…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Type 1 or type 2 diabetes treated with insulin
Exclusion Criteria:
1. Age \< 25 or \> 70 years.
2. HbA1c \> 10.0%
3. For female subjects: positive pregnancy test at the time of enrollment or study
4. History of prior upper abdominal surgery such as adjustable gastric banding…
Contacts