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Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 – 50
Sex
Female
Study type
Interventional
Purpose
Treatment
Participants needed
40 (estimated)
Sponsor
Medical University of South Carolina · Other
Who this trial is looking for
This trial is looking for women over 18 who have post-partum depression. Participants will receive transcranial magnetic stimulation treatment in two different schedules over several days to see how well they tolerate it and its effects on depression.
Are You a Good Fit for This Trial?
You may be able to join if
I can provide informed consent
I am over 18 years old
I have symptoms of post-partum depression
I have a HRSD17 score of 14 or higher
You may not be able to join if
I am currently pregnant
I have a substance use disorder
I have current psychotic symptoms
I have a history of dementia or cognitive impairment
I have active suicidal thoughts or have attempted suicide in the last 3 months
I have any issues that prevent me from receiving rTMS
I have unstable medical conditions
I had eclampsia during pregnancy
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
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Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Study 1: The investigators are studying the feasibility and tolerability of 10x/day intermittent theta burst (excitatory) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex over the course of 6 days for women with post-partum depression. The investigators further aim to characterize the anticipated anti-depressant effect of this treatment paradigm.
Study 2: The investiga…
Study 1: The investigators are studying the feasibility and tolerability of 10x/day intermittent theta burst (excitatory) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex over the course of 6 days for women with post-partum depression. The investigators further aim to characterize the anticipated anti-depressant effect of this treatment paradigm.
Study 2: The investigators are studying the feasibility and tolerability of 12 sessions/day of intermittent theta burse (excitatory) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex over 5 days for women with post-partum depression. The investigators aim to compare the two different treatment schedules.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Participants must be able to provide informed consent and function at an intellectual level sufficient to allow accurate completion of all assessment instruments.
2. Participants must be over the age of 18.
3. Participants must meet criteria for post-partum depression: a) ons…
Inclusion Criteria:
1. Participants must be able to provide informed consent and function at an intellectual level sufficient to allow accurate completion of all assessment instruments.
2. Participants must be over the age of 18.
3. Participants must meet criteria for post-partum depression: a) onset of symptoms in the first year postpartum
4. Participants must have a HRSD17 greater than or equal to 14 at baseline.
Exclusion Criteria:
1. Participants must not be pregnant.
2. Participants must not meet moderate or severe use disorder of any substance with the exception of Tobacco Use Disorder.
3. Participants must not have current psychotic symptoms.
4. Participants must not have a history of dementia or other cognitive impairment.
5. Participants must not have active suicidal ideation requiring hospitalization or a suicide attempt within the past 3 months.
6. Participants must not have any contraindications to receiving rTMS (e.g. metal implanted above the neck, history of seizure, any known brain lesion).
7. Participants must not have any unstable general medical conditions.
8. Participants must not have had eclampsia during pregnancy.
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