No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 85
Sex
Any
Study type
Interventional
Purpose
Diagnostic
Participants needed
96 (estimated)
Sponsor
Massachusetts General Hospital · Other
Who this trial is looking for
This trial is looking for healthy volunteers and patients with diabetes or aortic stenosis. Participants will undergo special imaging to help understand heart conditions better.
Are You a Good Fit for This Trial?
You may be able to join if
I am aged 18 to 85 years
I can provide informed consent
I have been diagnosed with diabetes
I have a recent echocardiogram without left ventricular hypertrophy
I have a recent echocardiogram showing aortic stenosis
I have no known history of medical disease
I have no history of cardiovascular disease
You may not be able to join if
I have a known contraindication to MRI
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The overall goal of this PET-MR imaging trial is to evaluate 11C-Martinostat, a histone deacetylase targeted radioligand, in patients with aortic stenosis, individuals with diabetes, and healthy volunteers.
Trial Locations
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City
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Status
Eligibility Criteria
Inclusion Criteria:
Group 1: Healthy Volunteers (n = 30)
* Healthy adults with no known history of medical disease
* Age 18-85 years
* No history cardiovascular disease
* Ability to provide informed consent
Group 2: Patients with Diabetes (n = 16)
* Age 18-85 years
* Diagnosis of diabetes
* Echo…
Inclusion Criteria:
Group 1: Healthy Volunteers (n = 30)
* Healthy adults with no known history of medical disease
* Age 18-85 years
* No history cardiovascular disease
* Ability to provide informed consent
Group 2: Patients with Diabetes (n = 16)
* Age 18-85 years
* Diagnosis of diabetes
* Echocardiogram within last 12 months showing no evidence of left ventricular hypertrophy or hemodynamic findings consistent with heart failure with preserved ejection fraction
* Ability to provide informed consent
Group 3: Patients with Aortic Stenosis (n = 50)
* Age 18-85 years
* Echocardiogram or cardiac MRI scan within last 12 months documenting left ventricular hypertrophy and degenerative calcific aortic stenosis
* Ability to provide informed consent
Exclusion Criteria:
* Known contraindication to MRI
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