No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
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At a Glance
Age
65 – 80
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
85 (estimated)
Sponsor
Georgia Institute of Technology · Other
Who this trial is looking for
This trial is looking for older adults aged 65 to 80 who can attend group testing sessions at Georgia Tech. Participants will take part in memory and navigation tasks to help researchers understand how aging affects memory and stress response.
Are You a Good Fit for This Trial?
Must not be takingBeta-blockers
Rules you outMultiple SclerosisSickle Cell AnemiaUntreated Diabetes
You may be able to join if
I am aged 65 to 80
I am a U.S. citizen or permanent resident
I speak fluent English
I am willing to come to Georgia Tech for testing
You may not be able to join if
I have epilepsy
I have dementia
I have Parkinson's disease
I have a history of stroke or seizure
I have a psychiatric disorder
I have untreated depression or emotional conditions
I have uncontrolled high or low blood pressure
I regularly use illegal or psychoactive drugs
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Two hallmarks of both healthy aging and age-related disease are 1) memory and navigational deficits, particularly in orienting towards goal locations and planning how to navigate to them, and 2) increased susceptibility to stress and altered regulation of the stress response. However, there are marked individual differences in these age-related changes. The investigators' proposal will help charac…
Two hallmarks of both healthy aging and age-related disease are 1) memory and navigational deficits, particularly in orienting towards goal locations and planning how to navigate to them, and 2) increased susceptibility to stress and altered regulation of the stress response. However, there are marked individual differences in these age-related changes. The investigators' proposal will help characterize factors that contribute to this variability.
Participants will be pseudorandomly assigned to stress-manipulated or control groups. The investigators will give both groups a novel immersive navigation task, validated by the PI in healthy young adults. This paradigm gives participants the opportunity to either (a) flexibly draw on spatial memory in order to plan efficient routes to goal locations, or (b) fall back on inefficient, but cognitively less-demanding, stimulus-response associations (i.e., habits). Using neuroimaging and behavioral measures, the investigators' protocol will test whether experimentally-induced stress leads individuals to bring fewer details about future locations to mind when route planning, and whether such restricted prospective thought ultimately biases participants towards relatively inflexible, habitual actions.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* adults 65-80
* U.S. citizens or permanent residents
* who speak fluent English
* willing to come to Georgia Tech to participate in group testing sessions.
Exclusion Criteria:
* Individuals will be carefully screened using IRB-approved procedures for safety contraindications …
Inclusion Criteria:
* adults 65-80
* U.S. citizens or permanent residents
* who speak fluent English
* willing to come to Georgia Tech to participate in group testing sessions.
Exclusion Criteria:
* Individuals will be carefully screened using IRB-approved procedures for safety contraindications to MRI and electrical shock stimulation
* (e.g., metal or electrical implants, heart arrhythmia, or medication affecting the cardiovascular system \[e.g. beta-blockers\]).
The purpose of this study is to investigate mechanisms of normally functioning memory, and memory-related changes in healthy aging. Thus, any confounding factors that may influence cognition, other than age, will be exclusionary. Potential participants that endorse any of the following conditions will be excluded from the study:
* Epilepsy
* Dementia
* Parkinson's disease
* history of stroke or seizure
* psychiatric disorders
* untreated depression or emotional conditions
* Attention Deficit Disorder
* Multiple Sclerosis
* uncontrolled hyper- or hypo-tension
* untreated Diabetes
* Sickle Cell Anemia
* regularly use illegal or psychoactive drugs (e.g., cocaine, alcohol abuse, etc).
* Additionally, individuals scoring \< 3 on WAIS-R forward span, \< 2 on WAIS-R backward span, and failing to name more than 2 vegetable names will be excluded from the study. These exclusions will insure that persons with mild cognitive impairment or typical indications of clinical dementia will be not participate in the research.
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