No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 80
Sex
Any
Study type
Observational
Participants needed
199 (estimated)
Sponsor
National Institute of Neurological Disorders and Stroke (NINDS) · NIH
Who this trial is looking for
This trial is looking for adults aged 18 and older who have had a stroke at least six months ago or healthy individuals between 18-35 and 50-80 years old. Participants will take part in tests to help researchers understand how naps might help with learning new motor skills.
Are You a Good Fit for This Trial?
Must not be takingSleep medications
Rules you outParkinson's diseaseMultiple sclerosis
You may be able to join if
I am at least 18 years old.
I have had a stroke that affected my upper body.
I can perform study tasks.
I speak English.
You may not be able to join if
I am currently pregnant.
I have had a large stroke in the brainstem or cerebellum.
I have a severe neurological disorder other than stroke.
I have uncontrolled heart, lung, kidney, or other serious disorders.
I cannot have an MRI or MEG.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Background:
Memory consolidation is the process by which memories become stable, long-term representations in the brain. Consolidation of a motor skill is dependent upon sleep. Some research shows that daytime naps improve people s motor performance and memory retention. Researchers want to find out how daytime naps may contribute to learning and support consolidation of motor skill memories.
Ob…
Background:
Memory consolidation is the process by which memories become stable, long-term representations in the brain. Consolidation of a motor skill is dependent upon sleep. Some research shows that daytime naps improve people s motor performance and memory retention. Researchers want to find out how daytime naps may contribute to learning and support consolidation of motor skill memories.
Objective:
To learn the role of memory replay during wakeful rest and sleep (naps) in retaining a newly learned skill.
Eligibility:
English-speaking adults ages 18 and older with chronic stroke, or healthy, right-handed, English-speaking adults ages 18-35 and 50-80
Design:
Participants will be screened with:
* medical history
* neurological history
* medicine review
* medical exam
* neurological exam.
Participants will have a magnetic resonance imaging (MRI) scan of the brain. For this, they will lie down in a scanner. The scanner makes loud noises, so they will wear earplugs. They will fill out an MRI screening form before each MRI.
Participants will also have magnetoencephalography (MEG). MEG maps brain activity. It does this by recording the magnetic fields produced by naturally occurring electrical currents in the brain. For MEG, participants will lie down in the MEG room. Their eye movements may be recorded by a video camera.
Participants will have behavior testing. They will practice typing random keys. Then they will repeatedly type a custom sequence that they see on a computer screen. Then they will take a 2-hour nap. Then they will type the same sequence again.
Participants will have no more than 4 visits at the NIH over 3 months. Visits will last 2-4 hours each.
Trial Locations
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City
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Status
Eligibility Criteria
* HEALTHY VOLUNTEERS:
INCLUSION CRITERIA:
* Age 18-35 (Arm 1) or 50-80 (Arms 2).
* English speaking.
* Clear right-hand dominance (\>74 on Edinburgh Handedness Inventory).
* Normal neurological examination as determined by the screening clinician.
EXCLUSION CRITERIA:
* HCPS affiliated NIH staff …
* HEALTHY VOLUNTEERS:
INCLUSION CRITERIA:
* Age 18-35 (Arm 1) or 50-80 (Arms 2).
* English speaking.
* Clear right-hand dominance (\>74 on Edinburgh Handedness Inventory).
* Normal neurological examination as determined by the screening clinician.
EXCLUSION CRITERIA:
* HCPS affiliated NIH staff (i.e. - staff from our section).
* Current pregnancy.
* Contraindications for MRI or MEG.
* Use of sleep medications within 24 hours of Experimental Session participation.
* Severe or progressive neurological, psychological or medical condition as determined by the screening clinician.
STROKE PATIENTS:
INCLUSION CRITERIA:
* Age 18 or older
* Willing and able to provide consent
* Experienced a stroke 6 months ago or more that affected at least one of the upper extremities at time of stroke diagnosis
* Ability to perform the study task as assessed during physical examination
* English-speaking
EXCLUSION CRITERIA:
* HCPS-affiliated NIH staff (i.e. - staff from our section).
* Current pregnancy
* History of large stroke lesions in brainstem or cerebellum as determined by screening clinician
* Severe or progressive neurological disorder other than stroke (e.g., Parkinson s disease or multiple sclerosis) as determined by the screening clinician
* Uncontrolled heart, lung, kidney, gastrointestinal, metabolic, psychiatric, sleep, or endocrine disorders as determined by the screening clinician
* Contraindications for MRI or MEG.
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