No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
50 – 85
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
30 (estimated)
Sponsor
VA Office of Research and Development · Federal
Who this trial is looking for
This trial is looking for veterans aged 50 and older with chronic kidney disease who can walk with or without a walking aid. Participants will engage in a combination exercise program to help improve muscle function and reduce fatigue.
Are You a Good Fit for This Trial?
You may be able to join if
I am 50 years of age or older.
I have been diagnosed with chronic kidney disease stages 3 or 4.
I can walk, with or without a gait aid.
I can read and speak English.
I am oriented to person, place, and time.
I have a kidney function test result of eGFR 59-15 ml/min per 1.73m2.
I do not have kidney disease symptoms in the last year.
I receive my renal care from the DC Veterans Affairs Medical Center.
You may not be able to join if
I have had acute renal failure or injury in the last 12 months.
I am not able to walk.
I do not receive my renal care from the DC Veterans Affairs Medical Center.
I have uncontrolled cardiovascular disease.
I have a musculoskeletal disease.
I have any serious health condition that might make it unsafe for me to participate.
I have orthopedic or joint pain that prevents me from exercising safely.
I plan to move out of the DC metro area within one year.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The VA health care system uses a health promotion-focused model which aims to provide longitudinal care through a patient-aligned care team for Veterans with chronic kidney disease. Since the largest subpopulation of Veterans with chronic kidney disease is comprised of those not requiring dialysis, neuromuscular screening assessments may provide valuable information regarding an individual overall…
The VA health care system uses a health promotion-focused model which aims to provide longitudinal care through a patient-aligned care team for Veterans with chronic kidney disease. Since the largest subpopulation of Veterans with chronic kidney disease is comprised of those not requiring dialysis, neuromuscular screening assessments may provide valuable information regarding an individual overall health status and potential for future complications. Furthermore, identifying at risk individuals early in the disease process will allow for the prescription of timely interventions. Exercise strategies such as combination exercise, which uses flywheel resistance plus aerobic exercise, may provide a valuable treatment option for combating neuromuscular dysfunction and functional decline in patients with chronic kidney disease.
Trial Locations
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City
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Status
Eligibility Criteria
Inclusion Criteria:
* Ambulatory (with or without a gait aid), 50 years of age or older diagnosed with chronic kidney disease (CKD) stages 3 \& 4 predialysis (as defined by eGFR 59-15 ml/min per 1.73m2)
* Control group will include ambulatory individuals without clinical evidence of kidney disease …
Inclusion Criteria:
* Ambulatory (with or without a gait aid), 50 years of age or older diagnosed with chronic kidney disease (CKD) stages 3 \& 4 predialysis (as defined by eGFR 59-15 ml/min per 1.73m2)
* Control group will include ambulatory individuals without clinical evidence of kidney disease (defined by eGRF \>60 ml/min per 1.73m2) within the last 12-months
* All participants must be able to speak and read English, and demonstrate orientation to person, place, and time
Exclusion Criteria:
* adults diagnosed with acute renal failure/injury within the last 12-months
* non-ambulatory individuals
* adults who do not use the DC VAMC as their main site for renal care
* those who have any uncontrolled cardiovascular
* musculoskeletal disease
* or other conditions that, in the opinion of the principal investigator, could make participation in the study unsafe
* any orthopedic or joint pain which would prevent the participant from safely engaging in the study protocol
* additionally, individuals with plans to relocate from the DC metro area within one year will not be eligible for the intervention portion of the study
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