Effects of THC-Free CBD Oil on Agitation in Patients With Alzheimer's Disease

Inclusion Criteria: * Males/females over 50 years old. * Have a diagnosis of dementia due to AD or mixed AD with another type of dementia. * A Mini-Mental State Exam score (MMSE) between 4 and 28 inclusive. * Presence of agitation with a Neuropsychiatric Inventory (NPI)-agitation/aggression subscore \> 3. * Participants and their informal caregivers must be fluent in English (includes reading, writing, and speech) and able to give informed consent. * For patients treated with cognitive-enhancing medications (cholinesterase inhibitors (ChEI) and/or memantine), the dosage must be stable for at least 1 month (30 days). If the ChEI and/or memantine has been discontinued, patients may enroll after 15 days. * Eligible caregivers must either live with the participant or have a minimum of 4 hours of daily contact with them. Exclusion Criteria: * Diagnosis of non-AD or non-mixed dementias. * Very mild dementia or advanced dementia (MMSE: greater than 28 or less than 4). * NPI-agitation-aggression score \< 3. * Having a serious or unstable medical illness including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease which might confound assessment of safety outcomes as determined by the study physician. * Presence or history of other serious psychiatric disorders or neurological conditions (e.g. psychotic disorders, bipolar disorder or schizophrenia). * Current abuse of/dependence on marijuana, current drug abuse, current alcohol abuse. * Having seizure disorders. * Pregnant or breastfeeding * Indication of baseline delirium as determined by the Confusion Assessment Method (CAM). * Current use of lithium. * Inability to swallow CBD oil softgels. * Changes in dosage of anti-depressives within 4 weeks before randomization and during the study. * Changes in dosage of antipsychotics or benzodiazepines within 1 week prior to randomization and during the study. * Contraindications to CBD oil (history of hypersensitivity to any cannabinoid). * Frequent falling due to orthostatic hypotension. * Use of tricyclic antidepressants (TCA), fluoxetine, and/or carbamazepine. -Patients who reside in nursing homes.