Cooled Radiofrequency Ablation for Knee Osteoarthritis

Fluoroscopic Versus Ultrasound Guidance for Cooled Radiofrequency Ablation of Geniculate Nerves in Knee Osteoarthritis: A Randomized Control Trial

Recruiting N/A Interventional Study
Knee Osteoarthritis
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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Review the details below, then apply to join this clinical trial.

At a Glance
Age
35 – 99
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
90 (estimated)
Sponsor
University of California, Davis · Other
Who this trial is looking for

This trial is looking for patients with knee osteoarthritis to compare two ways of guiding a treatment that may help relieve pain. Participants will receive cooled radiofrequency ablation targeting nerves around the knee.

Are You a Good Fit for This Trial?
Rules you out Rheumatoid arthritisPsoriatic arthritis

You may be able to join if

  • I have been diagnosed with knee osteoarthritis.
  • I am experiencing knee pain of at least four out of ten.
  • I have tried common treatments for at least three months without relief.
  • I have a Kellgren-Lawrence score of two to four.
  • I am at least 35 years old.
  • I can understand and speak English.
  • I need treatment on my most painful knee.

You may not be able to join if

  • I weigh more than 40 on the body mass index scale.
  • I have had previous knee joint replacement surgery.
  • I have active infections at the treatment site.
  • I have had a radiofrequency ablation procedure for my knee before.
  • I am unable to walk independently.
  • I have a pacemaker or similar device.
  • I have an unstable medical or psychiatric condition.
  • I cannot provide my own consent, like having dementia.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial
Cooled radiofrequency ablation (cRFA) of the knee geniculate nerves is a promising treatment option for knee osteoarthritis, but has variable efficacy. Fluoroscopy is the typical guidance of choice, but uses bony landmarks to target these nerves which have variable positions around the knee. Alternatively, ultrasound allows for targeting based on visualization of bony landmarks, the nerves, and th…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * 1\) patients of either gender with primary knee OA of one or both knees fulfilling the diagnostic criteria for knee OA by the American College of Rheumatology, * 2\) Kellgren-Lawrence score of two to four, * 3\) reported NPRS pain intensity of at least four on most or all days…
Contacts

Daniel Herman, MD

916-734-6805

dcherman@ucdavis.edu

CONTACT

Katherine Rizzone, MD

585-341-9407

katherine_rizzone@urmc.rochester.edu

CONTACT