Assessing Synaptic Density in Multiple Sclerosis
Assessment of Synaptic Density in MS
Recruiting
Early Phase 1
Interventional Study
Multiple Sclerosis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 60
- Sex
- Any
- Trial phase
- Early Phase 1
- Study type
- Interventional
- Purpose
- Diagnostic
- Participants needed
- 30 (estimated)
- Sponsor
- Brigham and Women's Hospital · Other
Who this trial is looking for
This trial is looking for people with multiple sclerosis (MS) to help researchers learn more about brain activity. Participants will undergo PET and MRI scans and provide blood samples for testing.
Are You a Good Fit for This Trial?
You may be able to join if
- I have been diagnosed with multiple sclerosis (MS).
- I can give informed consent.
- I am willing to undergo PET and MRI imaging.
- I am matched by age and sex to healthy controls.
You may not be able to join if
- I have a known alternate neurological disorder.
- I have had a head injury.
- I have a history of substance abuse.
- I have bipolar disorder or schizophrenia.
- I have other medical conditions that would prevent me from participating.
- I am pregnant or nursing.
- I have claustrophobia.
- I have an implanted device that is not MRI compatible.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
The investigators propose to use the novel SV2a-PET ligand, \[F-18\]SDM-8 to assess synaptic density in progressive multiple sclerosis (PMS) (including primary progressive multiple sclerosis (PPMS) and secondary progressive multiple sclerosis (SPMS)), given its improved imaging characteristics and potential for large scale applicability.
The specific aims of the study are:
Aim 1: To compare the …
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Subjects meeting the definition for MS (including PPMS, RRMS or SPMS) by International Panel (2017 McDonald) Criteria. Age and sex-matched healthy controls will also be recruited.
* Subjects willing to undergo PET and MRI imaging
* Subjects willing and able to give informed co…
Contacts