No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
30 – 55
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
150 (estimated)
Sponsor
University of Colorado, Denver · Other
Who this trial is looking for
This trial is looking for people who are overweight or have type 2 diabetes and do not exercise much. Participants will take part in an exercise program to see if it helps improve their insulin resistance and overall fitness.
Are You a Good Fit for This Trial?
Must not be takingBeta blockersCalcium channel blockersInsulinThiazolidinediones
Rules you outType 1 diabetesHepatic diseaseRenal disease
You may be able to join if
I do not exercise regularly.
I have a BMI between 25 and 40.
I am a man or woman with or without type 2 diabetes.
You may not be able to join if
I have a history of heart disease.
I have uncontrolled high blood pressure.
I have breathing problems like asthma or COPD.
I have peripheral neuropathy.
I have a physical issue that limits my ability to exercise.
I smoke or have smoked in the last year.
I have low iron levels (anemia).
I am pregnant, nursing, or on hormone therapy.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal to determine whether exercise training attenuates insulin resistance and restores insulin-mediated p…
The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal to determine whether exercise training attenuates insulin resistance and restores insulin-mediated perfusion to the heart and to skeletal muscle, leading to improved cardiac function and exercise performance.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Sedentary (defined as less than 1 hour per week of physical activity)
* BMI: 25-40
* Men and women with and without type 2 diabetes
Exclusion Criteria:
* Documented cardiovascular disease
* Uncontrolled hypertension: disease systolic blood pressure (SBP) \> 150, diastolic bl…
Inclusion Criteria:
* Sedentary (defined as less than 1 hour per week of physical activity)
* BMI: 25-40
* Men and women with and without type 2 diabetes
Exclusion Criteria:
* Documented cardiovascular disease
* Uncontrolled hypertension: disease systolic blood pressure (SBP) \> 150, diastolic blood pressure (DBP)\> 110
* Obstructive pulmonary disease or asthma
* Peripheral neuropathy
* Physical impairment that would limit exercise ability
* Subjects taking beta blockers, calcium channel blockers, insulin, or Thiazolidinediones (TZD)
* Current or past smoking within the last 1 years
* Current tobacco use
* Anemia
* Control HbA1c \> 5.7, T2DM HbA1c \> 9
* Pregnant, nursing or hormonal therapy (other than contraceptives)
* Peri or post-menopausal women
* Type 1 diabetes
* Hepatic or renal disease.
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