No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 40
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
46 (estimated)
Sponsor
University of Michigan · Other
Who this trial is looking for
This trial is looking for adults aged 18-40 who are overweight and don't exercise regularly. Participants will go through a weight loss program and then follow a high-calorie diet while being tested for changes in their metabolism.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 18 and 40 years old.
I have a body mass index (BMI) between 27 and 45.
I have not exercised regularly for at least 6 months.
If I am a woman, I have regular menstrual cycles and am not menopausal.
You may not be able to join if
I have a history of cardiovascular or metabolic disease.
I have used medications that affect lipid or glucose metabolism.
I have gained or lost more than 6 pounds in the last 3 months.
I use tobacco or e-cigarettes.
If I am a woman, I am pregnant or currently breastfeeding.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise training depending on group randomization). After completing this weight loss portion of the study, p…
Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise training depending on group randomization). After completing this weight loss portion of the study, participants will then be required to adhere to a high calorie diet program to regain half of the weight the participant lost - followed by the same series of metabolic tests.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age: 18-40
* Body Mass Index: 27-45 kg/m2
* No regularly planned exercise/physical activity for at least 6 months
* Women must have regularly occurring menses and must be premenopausal
Exclusion Criteria:
* Evidence/history of cardiovascular or metabolic disease
* Medication…
Inclusion Criteria:
* Age: 18-40
* Body Mass Index: 27-45 kg/m2
* No regularly planned exercise/physical activity for at least 6 months
* Women must have regularly occurring menses and must be premenopausal
Exclusion Criteria:
* Evidence/history of cardiovascular or metabolic disease
* Medications known to affect lipid or glucose metabolism, or inflammation
* Weight instability ≥ ± 6 pounds in the last 3 months
* Tobacco or e-cigarette users
* Women must not be pregnant or actively lactating
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