Understanding Puberty's Impact on Kidney Health in Diabetes
Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)
Recruiting
Observational Study
Type 2 Diabetes Mellitus
Diabetic Kidney Disease
Adolescent Obesity
Pre Diabetes
Kidney Hypoxia
Puberty
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 8 – 14
- Sex
- Any
- Study type
- Observational
- Participants needed
- 100 (estimated)
- Sponsor
- Petter Bjornstad · Other
Who this trial is looking for
This trial is looking for teenagers with type 2 diabetes and obesity. Participants will help researchers learn how puberty affects kidney health in young people with diabetes.
Are You a Good Fit for This Trial?
You may be able to join if
- I have type 2 diabetes.
- I have a body mass index (BMI) at or above the 85th percentile.
- I have not been treated for diabetes before.
- My blood sugar (HbA1c) is 6.0% or higher.
- I do not have type 1 diabetes antibodies.
- I have a normal blood sugar (HbA1c) level of 5.6% or lower if I am in the control group.
You may not be able to join if
- I have a history of chronic kidney disease.
- I have had an acute kidney injury.
- I have a metabolic disorder that makes fasting unsafe.
- I am allergic to iodine or penicillin.
- I am pregnant.
- I have a blood clotting disorder.
- I cannot have an MRI due to health reasons.
- I am currently taking hormone therapy.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death. Youth-onset T2D typically manifests during or shortly after puberty in adolescents with obesity. Epidemiological data implicate puberty as an accelerator of kidney disease in youth with obesity and diabetes and the investigators posit that the lin…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* HbA1c ≥6.0% for untreated high-risk group
* BMI ≥ 85th %ile for high-risk group
* Normal HbA1c ≤5.6% for control group
* Type 1 diabetes (T1D) Antibody negative
Exclusion Criteria:
* History of Chronic kidney disease (CKD) or acute kidney injury (AKI)
* Metabolic disorder pr…
Contacts