Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)
Recruiting
Observational Study
Type 2 Diabetes Mellitus
Diabetic Kidney Disease
Adolescent Obesity
Pre Diabetes
Kidney Hypoxia
Puberty
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 8 – 14
- Sex
- Any
- Study type
- Observational
- Participants needed
- 100 (estimated)
- Sponsor
- Petter Bjornstad · Other
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About This Trial
Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death. Youth-onset T2D typically manifests during or shortly after puberty in adolescents with obesity. Epidemiological data implicate puberty as an accelerator of kidney disease in youth with obesity and diabetes and the investigators posit that the lin…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* HbA1c ≥6.0% for untreated high-risk group
* BMI ≥ 85th %ile for high-risk group
* Normal HbA1c ≤5.6% for control group
* Type 1 diabetes (T1D) Antibody negative
Exclusion Criteria:
* History of Chronic kidney disease (CKD) or acute kidney injury (AKI)
* Metabolic disorder pr…
Contacts