Cognitive Behavioral Treatment for Depression in HIV Patients

Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)

Recruiting N/A Interventional Study
Depression HIV-1-infection Inflammation
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Other
Participants needed
150 (estimated)
Sponsor
Florida International University · Other
Who this trial is looking for

This trial is looking for adults living with HIV who have depression. Participants will receive a psychological treatment and undergo tests to see how it affects their gut health and brain function.

Are You a Good Fit for This Trial?
Must be taking Antiretroviral medications

You may be able to join if

  • I am 18 years or older
  • I can speak and read English
  • I have confirmed HIV+ status and take my medications
  • I have been diagnosed with Major Depressive Disorder
  • I have a stable dose of antidepressants for at least 2 months
  • My HIV viral load is suppressed
  • I can complete fMRI scans

You may not be able to join if

  • I cannot provide informed consent
  • I have an active, untreated major mental illness
  • I am pregnant
  • I have received CBT for depression in the past 2 years
  • I did not complete the necessary assessments and visits

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.

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About This Trial

The purpose of this randomized controlled trial is to understand how a cognitive-behavioral treatment (a form of psychological treatment) for depression changes the gut microbiome (micro-organisms that regulate the health of the gut), immune system, and the brain functioning in people living with HIV.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: 1. Age 18 or older 2. Speaks and reads English 3. Verified HIV+ status with antiretroviral medications bearing his/her name 4. Current diagnosis on Major Depressive Disorder (MDD) using a structured clinical interview (DIAMOND) or Hamilton Rating Scale for Depression scores of 7…
Contacts

Adam W Carrico, PhD

(305) 348-7887

acarrico@fiu.edu

CONTACT