Amantadine for Recovery After Stroke
Promoting Recovery After STroke With Amantadine
Recruiting
Phase 2
Interventional Study
Stroke, Ischemic
Stroke Hemorrhagic
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 – 85
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 60 (estimated)
- Sponsor
- University of Pennsylvania · Other
Who this trial is looking for
This trial is looking for people who have recently had a stroke. Participants will receive either the medication amantadine or a placebo for one month, while being monitored for their recovery over three months.
Are You a Good Fit for This Trial?
You may be able to join if
- I am between 18 and 85 years old.
- I had an ischemic or hemorrhagic stroke confirmed by medical testing.
- I am between 24 hours and 3 weeks after my stroke.
- I have a modified Rankin Score of 2 or less before my stroke.
- I have a National Institute of Health Stroke Scale score between 3 and 15.
- I have passed a swallow evaluation.
- I am a candidate for rehabilitation services.
- I can participate in tests.
You may not be able to join if
- I have any degree of receptive aphasia.
- I am currently pregnant or breastfeeding.
- I have a history of seizures.
- I have been diagnosed with dementia or mild cognitive impairment.
- I have had a prior stroke with lasting effects.
- I have a history of severe depression or suicidal thoughts in the past year.
- I have Parkinson's disease.
- I have an allergy to amantadine.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
The investigators aim to examine whether amantadine can help patients recover from stroke. This will be a blinded randomized clinical trial (RCT). Patients will be randomized post-ischemic or hemorrhagic stroke either to the placebo arm or amantadine arm. Patients will be on study drug or placebo for 1 month but will be enrolled for 3 months total. At various time points patients will be examined …
Trial Locations
Loading…
Loading trial locations…
Eligibility Criteria
Inclusion Criteria:
1. 18 to 85 years old, male and female
2. Modified Rankin Score (mRS)\<=2 prior to stroke
3. Ischemic or hemorrhagic stroke as diagnosed by vascular neurologist or as proven on magnetic resonance imaging (MRI) or non-contrast head computed tomography NCHCT)
4. 24 hours to 3 week…
Contacts