Fluoxetine or Escitalopram for Teen Depression
Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents With Depression
Recruiting
Observational Study
Depression in Adolescence
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 14 – 21
- Sex
- Any
- Study type
- Observational
- Participants needed
- 160 (estimated)
- Sponsor
- University of California, Los Angeles · Other
Who this trial is looking for
This trial is looking for teens aged 14-21 who are seeking treatment for depression. Participants will undergo tests to see how stress affects their inflammation levels and how these relate to their response to medication over 12 weeks.
Are You a Good Fit for This Trial?
You may be able to join if
- I am aged 14-21.
- I have been diagnosed with depression.
- I have not taken certain medications for at least 2-6 weeks.
- I am currently seeing a clinician for treatment.
- I can understand and complete study procedures.
- I have consent from my caregiver if needed.
You may not be able to join if
- I have a primary mental health diagnosis other than depression.
- I have had a concussion in the last 6 weeks.
- I have used stimulants.
- I cannot undergo MRI or blood tests.
- I have inflammatory conditions or take anti-inflammatory medications.
- I have major neurological or developmental disorders.
- I have a history of mania, psychosis, or substance use disorders.
- I have a first-degree relative with current or past mania or psychosis.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
Despite the prevalence and significant public health concern over depression among adolescents, up to 40% of depressed adolescents do not respond to first-line antidepressants (herein termed treatment non-response, TNR). The goal of this project is to recruit and assess 160 treatment-seeking depressed adolescents and test whether acute stress impacts peripheral levels of inflammation and downstrea…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* All sexes and genders
* All ethnicities
* Ages 14-21
* Postpubertal (Tanner stage \> 3)
* No medications that will interfere with the study (including antidepressants, mood stabilizers, hormone supplements, steroids, etc.) for at least 2-6 weeks (depending on exact medication)…
Contacts