Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents With Depression
Recruiting
Observational Study
Depression in Adolescence
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 14 – 21
- Sex
- Any
- Study type
- Observational
- Participants needed
- 160 (estimated)
- Sponsor
- University of California, Los Angeles · Other
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About This Trial
Despite the prevalence and significant public health concern over depression among adolescents, up to 40% of depressed adolescents do not respond to first-line antidepressants (herein termed treatment non-response, TNR). The goal of this project is to recruit and assess 160 treatment-seeking depressed adolescents and test whether acute stress impacts peripheral levels of inflammation and downstrea…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* All sexes and genders
* All ethnicities
* Ages 14-21
* Postpubertal (Tanner stage \> 3)
* No medications that will interfere with the study (including antidepressants, mood stabilizers, hormone supplements, steroids, etc.) for at least 2-6 weeks (depending on exact medication)…
Contacts