No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
180 (estimated)
Sponsor
University of Texas at Austin · Other
Who this trial is looking for
This trial is looking for adults with anxiety disorders, including PTSD and panic disorder, who want to try a breathing training program. Participants will use a device to help manage their breathing and learn about anxiety.
Are You a Good Fit for This Trial?
You may be able to join if
I have clinically elevated anxiety.
I am 18 years or older.
I can get to the study appointments.
I speak English fluently.
I have been diagnosed with an anxiety or trauma-related disorder.
You may not be able to join if
I have a medical condition that affects my heart or breathing.
I am currently in treatment for anxiety.
I have attempted suicide in the past 6 months.
I have had psychosis in the past 6 months.
I have a history of significant substance use issues in the past 3 months.
I am pregnant or breastfeeding.
I have COVID-19 symptoms.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Purpose of the Research: The primary aim of the proposed study is to conduct a randomized parallel-group 2-arm clinical trial investigating capnometry-guided respiratory intervention (CGRI) for pathological anxiety. CGRI aims to raise end-tidal CO2 levels thereby lowering hyperventilation-induced respiratory alkalosis and its associated fear-eliciting somatic reactions. Psycho-education about anxi…
Purpose of the Research: The primary aim of the proposed study is to conduct a randomized parallel-group 2-arm clinical trial investigating capnometry-guided respiratory intervention (CGRI) for pathological anxiety. CGRI aims to raise end-tidal CO2 levels thereby lowering hyperventilation-induced respiratory alkalosis and its associated fear-eliciting somatic reactions. Psycho-education about anxiety and its effects (PsyEd) will serve as a credible control comparator.
Trial Locations
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City
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Status
Eligibility Criteria
Inclusion Criteria:
1. Clinically elevated anxiety as indicated by an eight or higher on the Overall Anxiety Severity and Impairment Scale (OASIS).
2. Meets DSM-5 criteria for one or more of the following anxiety or trauma-related disorders as their "primary" mental disorder:
* Generalized Anxi…
Inclusion Criteria:
1. Clinically elevated anxiety as indicated by an eight or higher on the Overall Anxiety Severity and Impairment Scale (OASIS).
2. Meets DSM-5 criteria for one or more of the following anxiety or trauma-related disorders as their "primary" mental disorder:
* Generalized Anxiety Disorder
* Panic Disorder
* Health Anxiety
* Agoraphobia
* Social Anxiety Disorder
* Posttraumatic Stress Disorder
* Acute Stress Disorder
* Adjustment Disorder with primary anxious mood
* Anxiety disorder not otherwise specified
3. No current use of psychotropic medications or stable on current medications for at least 6 weeks
4. Age 18+.
5. Able to arrange transportation to our laboratory for study appointments.
6. Fluent in English.
Exclusion Criteria:
1. No history of medical conditions that would contraindicate participation in fear-provocation or respiratory challenges, including:
* Cardiovascular or respiratory disorders
* High blood pressure
* Epilepsy
* Strokes
* Seizures
* History of fainting
* Pregnant or lactating
2. Not currently receiving other psychological treatment for anxiety.
3. No history of a suicide attempt within the past 6 months.
4. No history of psychosis within the past 6 months.
5. No history of moderate to severe alcohol or substance use disorder (with the exception of nicotine) within the past 3 months.
6. Does not endorse COVID-19 symptoms during the screening phase.
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