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At a Glance
Age
30 – 50
Sex
Male
Study type
Interventional
Purpose
Other
Participants needed
5 (estimated)
Sponsor
University of California, Davis · Other
Who this trial is looking for
This trial is looking for adults who are interested in how Chardonnay marc may affect heart and blood vessel health. Participants will take part in testing and providing health information related to the study.
Are You a Good Fit for This Trial?
Must not be takingAspirinNSAIDs
Rules you outDiabetesHeart diseaseKidney diseaseLiver disease
You may be able to join if
I have a BMI between 25 and 35.
I can follow the study's procedures.
I agree to participate in all study activities.
I have a reactive hyperemia index of less than 2.0.
You may not be able to join if
I have a BMI of 35 or higher.
I weigh less than 110 pounds.
I donated blood in the last 30 days.
I have a reactive hyperemia index of 2.0 or higher.
I have a platelet count of less than 150,000.
I have been diagnosed with anemia.
I am allergic to nuts, cocoa, or grapes.
I have high blood pressure of 140/90 or higher.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study aims to obtain data on the potential influence of Vine to Bar product(s) containing Chardonnay marc on cardiometabolic health. These initial studies will inform the design and timing of data collection for future dietary intervention trials that will examine the influence of Chardonnay marc intake on outcomes/biomarkers of both cardiometabolic health and the gut microbiome. This include…
This study aims to obtain data on the potential influence of Vine to Bar product(s) containing Chardonnay marc on cardiometabolic health. These initial studies will inform the design and timing of data collection for future dietary intervention trials that will examine the influence of Chardonnay marc intake on outcomes/biomarkers of both cardiometabolic health and the gut microbiome. This includes collecting data on the potential differences in response to the products based on the unique food matrix for each of the products that will be tested. Moreover, as there is a paucity of data on the influence of cocoa flavanol intake on vascular function beyond 4 hours post intake, the response of the selected outcomes will be assessed after 6 hours of flavanol intake. This is a time point that captures the increased circulating presence of microbial derived flavanol metabolites.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Screening or Visit 1 Reactive Hyperemia Index (RHI; EndoPAT 2000) \< 2.0
* Subject is willing and able to comply with the study protocols.
* Subject is willing to participate in all study procedures
* BMI 25.0 - 35 kg/m2
Exclusion Criteria:
* BMI ≥ 35 kg/m2
* Indivduals that…
Inclusion Criteria:
* Screening or Visit 1 Reactive Hyperemia Index (RHI; EndoPAT 2000) \< 2.0
* Subject is willing and able to comply with the study protocols.
* Subject is willing to participate in all study procedures
* BMI 25.0 - 35 kg/m2
Exclusion Criteria:
* BMI ≥ 35 kg/m2
* Indivduals that weight less than a 110 lbs
* Donation of blood within the previous 30 days
* Visit 1 Reactive Hyperemia Index (RHI; EndoPAT 2000) ≥ 2.0
* 1 ug/ml and 3 ug/ml collagen screening maximal platelet aggregatory response of \< 65%.
* Platelet counts \< 150,000 / ul
* Anemia, which includes self report, or a screening hemoglobin and hematocrit that is less than the normal reference range or as diagnosed by study physician upon review of complete blood cell count reports.
* Dislike or allergy for nuts, cocoa or grape products
* Self-reported use of daily anticoagulation agents including aspirin, NSAIDs
* Vegan, Vegetarians, food faddists or those consuming a non-traditional diet
* Fruit consumption ≥ 3 cups/day
* Vegetable consumption ≥ 4 cups/day
* Nut intake ≥ 2 servings/ week
* Coffee/tea ≥ 3 cups/day
* Dark chocolate ≥ 3 oz/day
* Self-reported restriction of physical activity due to a chronic health condition
* Self-reported chronic/routine high intensity exercise
* Self-reported diabetes
* Blood pressure ≥ 140/90 mm Hg
* Self-reported renal or liver disease
* Self-reported heart disease, which includes cardiovascular events and stroke
* Peripheral artery disease, Raynaud's syndrome
* Inability to properly place or wear the PAT probes or abnormal measurements on pre- screening PAT
* Self-reported cancer within past 5 years
* Self-reported malabsorption
* Currently taking prescription drugs or supplements.
* Supplement use or unwillingness to stop any supplement use, including herbal, plant or botanical, fish oil, oil supplements a month prior to study enrollment.
* Indications of substance or alcohol abuse within the last 3 years
* smoking, vaping, cannabis use
* Current enrollee in a clinical research study.
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