Cognitive Training for Age-related Distractibility
The Role of the Locus Coeruleus in Age-related Distractibility
Recruiting
N/AInterventional Study
AgingAlzheimer Disease
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 75
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
200 (estimated)
Sponsor
Virginia Polytechnic Institute and State University · Other
Who this trial is looking for
This trial is looking for healthy adults aged 18 to 75 who want to help research on attention in older adults. Participants will take part in cognitive training to see if it can improve their ability to focus.
Are You a Good Fit for This Trial?
Rules you outLearning disabilitiesDevelopmental disabilities
You may be able to join if
I am a healthy adult
I am between 18 and 75 years old
I can provide written consent
You may not be able to join if
I have had surgery with metal implants
I may have metal fragments in my eyes
I have a pacemaker
I have a history of claustrophobia
I wear braces
I weigh over 250 pounds
I am pregnant or could become pregnant
I have severe medical or psychiatric conditions
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
A growing body of research has highlighted the importance of frontal regions, at both the functional and structural levels, in age-related declines in attentional and cognitive processing. However, the underlying neurobiological pathophysiological changes in the brain that contribute to these declines are still largely unclear. The objective of this proposal is to investigate neural mechanisms of …
A growing body of research has highlighted the importance of frontal regions, at both the functional and structural levels, in age-related declines in attentional and cognitive processing. However, the underlying neurobiological pathophysiological changes in the brain that contribute to these declines are still largely unclear. The objective of this proposal is to investigate neural mechanisms of age-related attentional distractibility, focusing on the neural circuit initiated from the locus coeruleus (LC). In the current proposal, the investigators will test the hypothesis that the neural disconnectivity of LC with the salience network (SN) drives failures of ignoring distractors in older adults. The investigators will examine how LC-SN connectivity is associated with selective attention performance, and how improved LC-SN connectivity through a cognitive training program may lead to improved attentional performance.
Trial Locations
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Eligibility Criteria
Inclusion:
* Healthy adult participants
* No younger than 18 and no older than 75 yrs of age
* Ability to provide written informed consent
Exclusion:
* History of surgery involving metal implants
* Possible metal fragments in the eyes
* Pacemaker
* A history of claustrophobia
* Braces
* Weighing …
Inclusion:
* Healthy adult participants
* No younger than 18 and no older than 75 yrs of age
* Ability to provide written informed consent
Exclusion:
* History of surgery involving metal implants
* Possible metal fragments in the eyes
* Pacemaker
* A history of claustrophobia
* Braces
* Weighing over 250 pounds
* Pregnant or possibility of being pregnant.
* Severe medical or psychiatric conditions (e.g., blind or deaf, head trauma)
* Learning disabilities or developmental disabilities
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