No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
13 – 18
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
90 (estimated)
Sponsor
Columbia University · Other
Who this trial is looking for
This trial is looking for adolescents aged 13-18 who struggle with depression. Participants will use a new mindfulness technique while their brain activity is monitored to see if it helps reduce their symptoms.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 13 and 18 years old
I have been diagnosed with major depressive disorder
I can speak and understand English
I have parental permission if I am under 18
I am at least at puberty stage 3
You may not be able to join if
I have a history of serious mental health disorders like psychosis or bipolar disorder
I have had active suicidal thoughts with a plan
I have had a seizure disorder
I have a medical condition that affects my brain or nervous system
I cannot have an MRI
I have used drugs heavily in the last 6 months
I take medications for mental health other than antidepressants
My IQ is below 80
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promising treatment target, as it is well-characterized at the neural level and contributes to depression onset, maintenance, and recurrence as well as predicts treatment non-response. Accordingly, the propos…
In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promising treatment target, as it is well-characterized at the neural level and contributes to depression onset, maintenance, and recurrence as well as predicts treatment non-response. Accordingly, the proposed research will investigate whether an innovative mindfulness-based real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention successfully elicits change in the brain circuit underlying rumination to improve clinical outcomes among depressed adolescents.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Ages 13-18 years-old
* Written informed assent/consent and parental/guardian permission for 13-17 year-olds or informed consent for 18 year-olds
* Tanner puberty stage ≥3
* Meets current diagnostic criteria for MDD
* English fluency
Exclusion Criteria:
* Lifetime history of …
Inclusion Criteria:
* Ages 13-18 years-old
* Written informed assent/consent and parental/guardian permission for 13-17 year-olds or informed consent for 18 year-olds
* Tanner puberty stage ≥3
* Meets current diagnostic criteria for MDD
* English fluency
Exclusion Criteria:
* Lifetime history of primary psychotic disorders, bipolar disorder, oppositional defiant disorder, conduct disorder, developmental disorder (e.g., autism), post-traumatic stress disorder, or eating disorders
* Substance use disorder, moderate or severe in past 6 months
* Active suicidal ideation with a specific plan
* History of seizure disorder
* Medical or neurological illness (e.g., severe head injury)
* MRI contraindications
* Current psychotropic medication use other than antidepressant medication
* Intelligence quotient (IQ) \<80.
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