taVNS or TMS for Depression
taVNS or TMS or Both for Depression
Recruiting
N/A
Interventional Study
Depression
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 75
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 24 (estimated)
- Sponsor
- Medical University of South Carolina · Other
Who this trial is looking for
This trial is looking for adults with depression who might benefit from two types of treatments. Participants will receive either ear nerve stimulation, brain stimulation, or both, over several visits at a clinic.
Are You a Good Fit for This Trial?
You may be able to join if
- I am between 18 and 75 years old.
- I have tried two antidepressant medications that did not work.
- I can understand and sign consent forms.
- I speak and read English.
- I have a depression score of 20 or higher on a specific scale.
- I have not improved with talking therapy.
You may not be able to join if
- I have a neurological disorder or dementia.
- I have had major head trauma.
- I am expected to live less than a year.
- I have any cognitive impairment that requires someone else to consent for me.
- I have a high suicidality score on a specific scale.
- I have an active plan to harm myself or have attempted to in the last 6 months.
- I am currently pregnant or might be pregnant.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
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About This Trial
The purpose of the research is to test out a combined treatment for depression where the investigators stimulate a nerve in the ear while at the same time stimulate the brain with magnets. These treatments are called transcutaneous (through the skin) auricular (ear) vagus nerve stimulation (taVNS) and transcranial (through the skull) magnetic stimulation (TMS). For participants who already have a …
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* 18-75 years old
* Undergoing cervical VNS or have tried and failed two antidepressant medications in the current episode
* Able to provide informed consent
* English speaking and can read and write
* 17-item Hamilton Depression Rating Scale (HAM-D) score ≥20
* Not responding t…
Contacts