No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 85
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
100 (estimated)
Sponsor
Indiana University · Other
Who this trial is looking for
This trial is looking for people who have had a stroke within the last 1 to 6 months. Participants will take part in a walking therapy program to help improve their ability to move and enjoy life more.
Are You a Good Fit for This Trial?
You may be able to join if
I have had a stroke 1 to 6 months ago.
I can walk 10 meters with or without help but slower than 1.0 m/s.
I can sit for more than 30 seconds without assistance.
I can follow 3-step commands.
I can give consent or have someone authorized to consent for me.
You may not be able to join if
I have a serious heart or lung disease that makes exercising difficult.
I displayed serious symptoms during a treadmill test.
I had any walking problems that limited me to less than 50 meters before my stroke.
I cannot receive physical therapy once the trial starts.
I am prescribed more than 50 units of botulinum toxin in leg muscles above the knee.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The proposed research will evaluate the individual and combined effects of task-specificity and intensity of rehabilitation interventions on locomotor function, community mobility and quality of life in patients with subacute (1-6 months) post-stroke.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Sub-acute stroke (1-6 months)
* Hemiparesis (Fugl-Meyer \<34) without cerebellar deficits
* Ability to ambulate with or without physical assistance over 10 meters but \< 1.0 m/s and assistive devices and below-knee bracing is allowed.
* Ability to sit \> 30 seconds without upp…
Inclusion Criteria:
* Sub-acute stroke (1-6 months)
* Hemiparesis (Fugl-Meyer \<34) without cerebellar deficits
* Ability to ambulate with or without physical assistance over 10 meters but \< 1.0 m/s and assistive devices and below-knee bracing is allowed.
* Ability to sit \> 30 seconds without upper-extremity support or physical assistance
* Ability to follow 3-step commands
* Provision of informed consent and medical clearance from a supervising physician or medical provider to participate
* Must have the ability to consent or have a legal health care power of attorney or legally authorized representative to consent for participation on their behalf
Exclusion Criteria:
* Significant cardiovascular, metabolic, or respiratory disease that limits exercise participation (e.g. previous myocardial infarction \< 3 months prior, uncompensated congestive heart failure, resting blood pressure \> 210/110 mmHg, uncontrolled diabetes, end-stage renal disease, severe infectious or psychiatry disease, or advanced malignancy)
* If during the graded-treadmill exercise evaluation, the participant presents with absolute criteria for termination of exercise testing during initial testing (e.g. moderate to severe angina, ST elevation \> 1.0mm without preexisting Q wave secondary to prior MI, signs of poor perfusion, etc).
* Any orthopedic or neurological disorders that limited walking to \<50m prior to stroke onset.
* Cannot receive physical therapy once baseline testing begins
* If patients are prescribed botulinum toxin for their lower extremities will be excluded only if the dosage for any specific muscle is \>50 units in leg muscles above the knee. If doses are \> than 50 units in leg muscles below the knee, the participant will use an ankle-foot orthosis to minimze contributions of those mscles to locomotor function.
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