Semaglutide for Advanced Lung Disease
Feasibility of Semaglutide in Advanced Lung Disease
Recruiting
Phase 1
Phase 2
Interventional Study
Obesity
Interstitial Lung Disease
Chronic Obstructive Pulmonary Disease
Sarcoidosis, Pulmonary
Pulmonary Hypertension
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 – 80
- Sex
- Any
- Trial phase
- Phase 1/2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 8 (estimated)
- Sponsor
- University of Pennsylvania · Other
Who this trial is looking for
This trial is looking for patients with advanced lung disease who are overweight. Participants will take a medication called semaglutide for 12 weeks and will have some health tests and surveys about side effects.
Are You a Good Fit for This Trial?
You may be able to join if
- I have been diagnosed with a lung disease.
- I am over 18 years old.
- I have a BMI over 30.
- I need oxygen when I exercise.
- I have been on stable treatment for 90 days.
- I am using a therapy that changes my lung disease.
You may not be able to join if
- I have diabetes.
- I am pregnant or breastfeeding.
- I have lost weight recently.
- I have had stomach issues recently or in the past.
- I have a history of gastroparesis.
- I have a history of scleroderma.
- I am in the hospital right now.
- I have used weight loss medication in the last 90 days.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
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About This Trial
The goal of this clinical trial is to learn whether semaglutide, an FDA-approved treatment for diabetes and obesity, is feasible and tolerable in patients with advanced lung disease.
The main question\[s\] it aims to answer are:
1. Are patients with advanced lung disease able to tolerate semaglutide therapy?
2. Are we able to titrate semaglutide therapy to a target weight?
Participants will be …
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Diagnosis of one of the following lung diseases: interstitial lung disease, sarcoidosis, chronic obstructive pulmonary disease, or pulmonary hypertension
* Age \> 18
* BMI \> 30 kg/m2
* Requires supplemental oxygen on exertion
* Stable treatment regimen X 90 days
* Use of dise…
Contacts