Pasritamig with Other Treatments for Prostate Cancer
A Study of Pasritamig (JNJ-78278343) in Combination With Other Agents for Metastatic Prostate Cancer
- Age
- 18 and older
- Sex
- Male
- Trial phase
- Phase 1
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 300 (estimated)
- Sponsor
- Janssen Research & Development, LLC · Industry
This trial is looking for men with advanced prostate cancer to test a new treatment called pasritamig combined with other medications. Participants will need to have already received certain types of cancer treatments before joining the trial.
You may be able to join if
- I have metastatic castration-resistant prostate cancer or metastatic hormone-sensitive prostate cancer.
- I have confirmed adenocarcinoma of the prostate.
- I have a PSA level of at least 2 ng/mL.
- I have measurable or evaluable disease.
- I have prior treatment with at least one androgen receptor pathway inhibitor.
- I have an ECOG performance status of 0 or 1.
- I have adequate organ functions.
You may not be able to join if
- I have an active autoimmune disease requiring immunosuppressive medications.
- I have not recovered from side effects of previous cancer treatments.
- I have had a solid organ or bone marrow transplant.
- I have known allergies to the study medications.
- I have significant infections or serious medical conditions.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your EligibilityThe purpose of this study is to identify the recommended phase 2 regimen(s) RP2R(s) of pasritamig and combination regimens in Part 1 (dose escalation) and to determine safety at the putative RP2R(s) of pasritamig with the combination regimens in Part 2 (dose expansion).
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