Pasritamig with Other Treatments for Prostate Cancer

A Study of Pasritamig (JNJ-78278343) in Combination With Other Agents for Metastatic Prostate Cancer

Recruiting Phase 1 Interventional Study
Metastatic Castration-resistant Prostate Neoplasms Metastatic Hormone-sensitive Prostate Cancer
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 and older
Sex
Male
Trial phase
Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
300 (estimated)
Sponsor
Janssen Research & Development, LLC · Industry
Who this trial is looking for

This trial is looking for men with advanced prostate cancer to test a new treatment called pasritamig combined with other medications. Participants will need to have already received certain types of cancer treatments before joining the trial.

Are You a Good Fit for This Trial?

You may be able to join if

  • I have metastatic castration-resistant prostate cancer or metastatic hormone-sensitive prostate cancer.
  • I have confirmed adenocarcinoma of the prostate.
  • I have a PSA level of at least 2 ng/mL.
  • I have measurable or evaluable disease.
  • I have prior treatment with at least one androgen receptor pathway inhibitor.
  • I have an ECOG performance status of 0 or 1.
  • I have adequate organ functions.

You may not be able to join if

  • I have an active autoimmune disease requiring immunosuppressive medications.
  • I have not recovered from side effects of previous cancer treatments.
  • I have had a solid organ or bone marrow transplant.
  • I have known allergies to the study medications.
  • I have significant infections or serious medical conditions.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

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About This Trial

The purpose of this study is to identify the recommended phase 2 regimen(s) RP2R(s) of pasritamig and combination regimens in Part 1 (dose escalation) and to determine safety at the putative RP2R(s) of pasritamig with the combination regimens in Part 2 (dose expansion).

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Part 1 A-G, 1I, 1J, and 1K (all combination treatments) and Parts 2B-C (cabazitaxel, docetaxel): Metastatic castration-resistant prostate cancer (mCRPC) with confirmed adenocarcinoma of the prostate as defined by prostate cancer working group 3 (PCWG3); Parts 2D-G, 2I, 2J, and…
Contacts

Study Contact

844-434-4210

Participate-In-This-Study1@its.jnj.com

CONTACT