No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
306 (estimated)
Sponsor
Baylor College of Medicine · Other
Who this trial is looking for
This trial is looking for veterans and service members with anxiety disorders and PTSD. Participants will receive different types of therapy to compare their effectiveness in improving symptoms and quality of life.
Are You a Good Fit for This Trial?
You may be able to join if
I am a veteran or service member at least 18 years old.
I have been diagnosed with at least one anxiety-based disorder.
I have a moderate-to-poor enjoyment of life, with a score of 47 or lower on a specific assessment.
I have been stable on my medication for at least 4 weeks.
I am willing to participate in random assignment to different treatment options.
You may not be able to join if
I have active symptoms of mania or psychosis.
I have depression with thoughts of suicide that would prevent treatment.
I have moderate-to-severe cognitive impairment.
I have a substance or alcohol dependency and cannot limit my use during treatment.
I am currently receiving other specific therapies for my anxiety disorders.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The goal of this clinical trial is to compare two different intensive formats of delivering cognitive-behavioral treatment for people with PTSD and anxiety disorders. The main questions it aims to answer are:
* Is iTCBT delivered in individual and group formats more effective than TAU in improving anxiety symptoms and quality of life?
* For treatment non-responders, is iTCBT-Enhanced more effecti…
The goal of this clinical trial is to compare two different intensive formats of delivering cognitive-behavioral treatment for people with PTSD and anxiety disorders. The main questions it aims to answer are:
* Is iTCBT delivered in individual and group formats more effective than TAU in improving anxiety symptoms and quality of life?
* For treatment non-responders, is iTCBT-Enhanced more effective than TAU improving anxiety symptoms and quality of life?
* Does iTCBT-Individual produce a larger improvement in anxiety and quality of life compared with iTCBT-Group?
Participants will undergo several assessments throughout the course of the study. Based on randomization, they will receive: (1) iTCBT in an individual format over a 2-week period, (2) iTCBT in a group format over a 2-day period, or (3) usual care. Those who do not show a response to treatment will receive 4 additional individual therapy sessions.
Trial Locations
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City
State
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Status
Eligibility Criteria
Inclusion Criteria:
* Veteran/Service Member at least 18 years old
* Current diagnosis of at least one anxiety-based disorder: Posttraumatic Stress Disorder, Panic Disorder, Social Anxiety Disorder, Generalized Anxiety Disorder, Other Specified Trauma- and Stressor-Related Disorder, Other Specified…
Inclusion Criteria:
* Veteran/Service Member at least 18 years old
* Current diagnosis of at least one anxiety-based disorder: Posttraumatic Stress Disorder, Panic Disorder, Social Anxiety Disorder, Generalized Anxiety Disorder, Other Specified Trauma- and Stressor-Related Disorder, Other Specified Anxiety Disorder, and Unspecified Anxiety Disorder (based on ADIS-5)
* Moderate-to-poor life enjoyment and satisfaction as indicated by a score of 47 or lower on the QLES-Q-SF
* Stable on psychotropic medication for 4 weeks before study participation
* Willing to be randomized to treatment condition
Exclusion Criteria:
* Active symptoms of mania or psychosis at baseline (based on ADIS-5)
* Depression with active suicidal ideation and intent that would preclude treatment (based on ADIS-5 \& BDI-II)
* Moderate-to-severe cognitive impairment as indicated by the SLUMS (a score below 20)
* Veterans/Service Members with comorbid substance/alcohol use or dependence are study eligible but must agree to reduce and limit their use of substances during the active course of treatment, particularly during exposure exercises. If they do not agree to this, they will be excluded
* Undergoing concurrent transdiagnostic CBT specifically targeting any of the above-mentioned disorders
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