Studying Brain Mechanisms in Psychotic Alzheimer’s Disease

Tau Networks in Psychotic Alzheimer's Disease

Recruiting Observational Study
Alzheimer Disease Alzheimer Disease With Delusions Alzheimer Disease With Psychosis
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Healthy Volunteers Welcome You do not need to have the condition being studied to take part. No Study Drug Researchers observe your health over time — no experimental treatment is given.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
65 – 85
Sex
Any
Study type
Observational
Participants needed
91 (estimated)
Sponsor
Northwell Health · Other
Who this trial is looking for

This trial is looking for older adults with Alzheimer’s disease who experience psychotic symptoms, such as hallucinations or delusions. Participants will help researchers understand how certain brain changes are related to these symptoms.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am between 65 and 85 years old.
  • I have been diagnosed with probable Alzheimer’s disease.
  • I have a Mini-Mental State Examination score between 10 and 26.
  • I have a Clinical Dementia Rating score of at least 0.5.
  • I have the required Logical Memory delay score based on my education level.
  • I have psychotic symptoms, like hallucinations or delusions.

You may not be able to join if

  • I have had a stroke.
  • I have a significant neurological disorder other than Alzheimer’s.
  • I have a serious psychiatric disorder, like schizophrenia or bipolar disorder.
  • I have a history of alcoholism or drug dependency in the last 5 years.
  • I have metal implants like a pacemaker.
  • I cannot lie flat for about one hour.
  • I have trouble hearing sounds at specific frequencies.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.

Check Your Eligibility
About This Trial
This research project aims to understand the brain mechanisms behind the manifestation of psychotic symptoms in Alzheimer´s disease (AD), and nature of the unique relationship with tau pathology. Amongst the cognitive manifestations of psychosis are impairments related to frontal circuits (social cognition, working memory and executive function deficits). The investigator's previous work suggests …
Trial Locations
Loading…

Loading trial locations…

Eligibility Criteria
Inclusion Criteria Alzheimer´s disease (AD) participants: * Age 65-85 years old. * Diagnosis of probable AD dementia according to National Institute on Aging-Alzheimer's Association (NIA-AA) criteria. * Mini-Mental State Examination (MMSE) score ≥ 10 and ≤ 26 at the screening visit. * Clinical Deme…
Contacts

Erica Christen, MS

516-562-3492

EChriste@northwell.edu

CONTACT

Michelle Gong, AS

516-562-3492

MGong@northwell.edu

CONTACT