No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
40 and older
Sex
Any
Study type
Interventional
Purpose
Other
Participants needed
60 (estimated)
Sponsor
University of Colorado, Denver · Other
Who this trial is looking for
This trial is looking for people with chronic obstructive pulmonary disease (COPD) to learn more about how their heart works during rest and exercise. Participants will undergo some tests related to their heart and lungs to help find better treatments for COPD in the future.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with COPD
I am 40 years or older
You may not be able to join if
I have had a worsening of my COPD in the last 3 months
I have changed my COPD treatment in the last 3 weeks
I need more than 6 liters per minute of oxygen at rest
I need more than 10 liters per minute of oxygen when I exercise
I have untreated severe obstructive sleep apnea
I am pregnant
My body mass index is less than 18 or greater than 40
I have a serious heart condition
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study plans to learn about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patterns of right ventricular dysfunction, this study will help identify better treatments for patients with C…
This study plans to learn about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patterns of right ventricular dysfunction, this study will help identify better treatments for patients with COPD in the future.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* COPD (determined by ratio of forced expiratory volume in 1 second to forced vital capacity \[FEV1/FVC\] \<0.7)
* Age \>= 40 years
Exclusion Criteria:
* Exacerbation of COPD in the 3 months prior to enrollment
* Change in COPD therapy in the 3 weeks prior to enrollment
* Requ…
Inclusion Criteria:
* COPD (determined by ratio of forced expiratory volume in 1 second to forced vital capacity \[FEV1/FVC\] \<0.7)
* Age \>= 40 years
Exclusion Criteria:
* Exacerbation of COPD in the 3 months prior to enrollment
* Change in COPD therapy in the 3 weeks prior to enrollment
* Requirement of \>6 LPM supplemental oxygen at rest
* Requirement of \>10 LPM supplemental oxygen with exertion
* Active/uncontrolled cardiovascular disease (e.g. hypertension with blood pressure \>150/100 despite antihypertensives; coronary artery disease with angina; left ventricular ejection fraction ≤40%; arrhythmia; pulmonic, mitral or aortic valvular abnormality greater than mild in severity; tricuspid regurgitation greater than moderate in severity)
* Volume overload (jugular vascular distension or greater than trace peripheral edema)
* World Health Organization Functional Class IV
* Known pulmonary hypertension with mean pulmonary artery pressure \>45 mmHg
* Untreated severe obstructive sleep apnea or obesity hypoventilation syndrome
* Active malignancy (other than skin)
* Medical conditions that limit exercise on an upright stationary bicycle (e.g. severe osteoarthritis, imbalance/gait instability, etc.)
* Pregnancy
* Body mass index \<18 or \>40
* Hematocrit \<25% or \>55%
* For invasive CPET, chronic anticoagulation that is unable to be held for the study visit
* For invasive CPET, forced expiratory volume in 1 second of \<20%
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