Electroconvulsive Therapy for Treatment-Resistant Depression

Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy

Recruiting Observational Study
Treatment Resistant Depression
No Study Drug Researchers observe your health over time — no experimental treatment is given.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
21 – 65
Sex
Any
Study type
Observational
Participants needed
50 (estimated)
Sponsor
Washington University School of Medicine · Other
Who this trial is looking for

This trial is looking for people who have treatment-resistant depression and will be receiving electroconvulsive therapy (ECT). Participants will help researchers understand how ECT affects sleep and brain function.

Are You a Good Fit for This Trial?

You may be able to join if

  • I have treatment-resistant depression.
  • I am referred for my first course of electroconvulsive therapy.
  • I have tried at least two antidepressant medications without success.

You may not be able to join if

  • I have schizophrenia or a schizoaffective disorder.
  • I cannot tolerate the Dreem device for sleep recordings.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.

Check Your Eligibility
About This Trial

Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Referral for initial ECT index course for Treatment-Resistant Depression (TRD), unipolar major depressive disorder or bipolar depression. Historic failure of response or remission to at least two antidepressant medications of sufficient dose and duration will be used for TRD d…
Contacts

Robby Greenspan

314-273-6129

greenspan@wustl.edu

CONTACT

MohammadMehdi Kafashan

314-273-8848

kafashan@wustl.edu

CONTACT