Engage & Connect Treatment for Suicidal Thoughts

Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality

Recruiting N/A Interventional Study
Depression Suicidal Ideation Major Depressive Disorder Depressive Disorder
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
50 – 80
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
128 (estimated)
Sponsor
Weill Medical College of Cornell University · Other
Who this trial is looking for

This trial is looking for older adults with major depression and thoughts of suicide. Participants will take part in a 9-week treatment and have their brain activity monitored to see if it helps reduce suicidal thoughts.

Are You a Good Fit for This Trial?
Must not be taking Lorazepam
Rules you out Generalized anxiety disorderSpecific phobia

You may be able to join if

  • I am between 50 and 80 years old.
  • I have thoughts of suicide.
  • I have been diagnosed with major depressive disorder.
  • I have a depression rating score of 16 or higher.
  • I have a Mini Mental Status Exam score of 23 or higher.
  • I have been on a stable dose of an antidepressant for at least 8 weeks.
  • I can give consent for research.
  • I do not receive individual psychotherapy during the study.

You may not be able to join if

  • I have a plan or intention to attempt suicide soon.
  • I have psychiatric diagnoses other than major depressive disorder.
  • I take medications like psychotropic drugs not allowed in this trial.
  • I have neurological disorders such as dementia or Parkinson's disease.
  • I had a serious medical illness in the last 3 months.
  • I cannot undergo an MRI scan due to certain medical implants.
  • I have claustrophobia that prevents me from using an MRI.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial

The investigators hypothesized that during the 9-week course of Engage \& Connect treatment there will be an increase in brain functions of the Positive Valence System which in turn will lead to reduction in suicidality.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Ages aged 50-80 \[stratified so that 50% are older than 65\] * Endorsement of Suicidal Ideation \[Structured Clinical Interview for the Diagnostic and Statistical Manual for Mental Disorders-5 (SCID-5) Suicide Item (Item 9) with a score of 2 * Major Depressive Disorder as dete…
Contacts

Nili Solomonov, PhD

(914) 682-9100

nis2051@med.cornell.edu

CONTACT