No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
21 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
60 (estimated)
Sponsor
Johns Hopkins University · Other
Who this trial is looking for
This trial is looking for adults who have had a stroke within the last 6 weeks and have difficulty using their arm or hand. Participants will compare regular therapy with additional self-directed exercises at home to improve hand function.
Are You a Good Fit for This Trial?
Rules you outSevere arthritisSevere neuropathyParkinson's disease
You may be able to join if
I am 21 years old or older
I have had a stroke confirmed by a CT or MRI in the last 6 weeks
I have arm and/or hand problems because of my stroke
I am enrolled in JSTTEP
I have been admitted to Johns Hopkins Hospital for stroke treatment
I can speak and read English
I am willing to have remote follow-ups for the study
I can give my consent
You may not be able to join if
I have very severe arm problems on the day of testing
I have had a Botox injection in my arm since I had my stroke
I have a condition that affects my ability to participate in the study
I have a terminal illness with less than 6 months to live
I cannot sit and do hand exercises for 20 minutes
I have cognitive impairment score below 21 on the MoCA
My personal situation prevents me from having telemedicine follow-ups
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study aims at comparing manual function outcomes between the standard of care and additional self-administered hand therapy after stroke. Strokes are common neurological injuries, and although rates of survival have increased in recent decades, survivors often continue to experience deficiencies in hand dexterity and bimanual function. Most motor recovery takes place within the first 3 months…
This study aims at comparing manual function outcomes between the standard of care and additional self-administered hand therapy after stroke. Strokes are common neurological injuries, and although rates of survival have increased in recent decades, survivors often continue to experience deficiencies in hand dexterity and bimanual function. Most motor recovery takes place within the first 3 months after a stroke. This initial period is necessary for stabilizing the patient but also provides different opportunities to foster motor recovery. Functional gains, including instances after the post-acute period, have been observed after regular and frequent (high dosage) therapy, suggesting that recovery is likely influenced by practice-driven sensorimotor learning. These findings motivate the implementation of daily therapeutic regimes beyond post-stroke hospitalization and basic motor function, aiming instead at addressing overlooked deficiencies in manipulation and bimanual coordination. While some hand therapy is often provided during outpatient therapy visits (the standard of care), self-administered sessions play a large role in implementing additional daily therapy. As a result, the investigators are interested in both the implementation of self-administered regimes and measuring clinical outcomes with and without self-administered therapy.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Age 21 years and over
2. Stroke confirmed by CT or MRI within the previous 6 weeks.
3. Arm and/or hand impairment induced by the stroke.
4. Meet JSTTEP criteria and are enrolled in JSTTEP.
5. Admitted to the Johns Hopkins Hospital (JHH) inpatient stroke service.
6. Proficient…
Inclusion Criteria:
1. Age 21 years and over
2. Stroke confirmed by CT or MRI within the previous 6 weeks.
3. Arm and/or hand impairment induced by the stroke.
4. Meet JSTTEP criteria and are enrolled in JSTTEP.
5. Admitted to the Johns Hopkins Hospital (JHH) inpatient stroke service.
6. Proficient in speaking and reading English.
7. Willing and capable to contacted remotely for all necessary telemedicine contacts.
8. No history of prior ischemic or hemorrhagic stroke with associated motor deficits (prior stroke with no upper limb motor symptoms is allowed)
9. Ability to give informed consent.
Exclusion Criteria:
1. Arm impairment that is too severe (FM-UE \< 40) on day of baseline testing prior to beginning of the study.
2. Recent Botox injection to upper limb (since stroke onset).
3. History of physical or neurological condition that interferes with study procedures or assessment of motor function (e.g. severe arthritis, severe neuropathy, Parkinson's disease).
4. Terminal illness with life expectancy \< 6 months.
5. Inability to sit in a chair and perform hand exercises for 20 minutes at the time.
6. Cognitive impairment, with score on Montreal Cognitive Assessment (MoCA) ≤ 20.
7. Social and/or personal circumstances that prevent telemedicine follow-up.
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