No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 65
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
100 (estimated)
Sponsor
The University of Texas at Dallas · Other
Who this trial is looking for
This trial is looking for people with relapsing-remitting multiple sclerosis who have trouble remembering things. Participants will receive low-level electrical stimulation to see if it helps improve their memory.
Are You a Good Fit for This Trial?
Must not be takingAnti-convulsantsL-dopaCarbamazepineSulpiridePergolideLorazepam
Rules you outDementiaEpilepsySevere traumatic brain injuryBrain tumorDrug abuseStrokeBlood vessel abnormalities in the brainParkinson's disease
You may be able to join if
I have been diagnosed with relapsing-remitting multiple sclerosis
I have a memory retrieval deficit
I can speak and read English
You may not be able to join if
I have had a relapse or acute MS worsening in the last two months
I have used steroids in the last two months
I am using benzodiazepines but have not been on a stable dose for two months
I have a history of dementia, seizures, or severe brain trauma
I have a current brain tumor or drug abuse issues
I have had a stroke or blood vessel problems in the brain
I have Parkinson's disease or Huntington's disease
I cannot give informed consent
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., presupplementary motor area) thought to aid in memory will improve verbal retrieval in multiple sclerosis patients. The primary outcome measures are neuropsychological assessments of verbal retrieval, and the secondary measures are neuro…
The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., presupplementary motor area) thought to aid in memory will improve verbal retrieval in multiple sclerosis patients. The primary outcome measures are neuropsychological assessments of verbal retrieval, and the secondary measures are neuropsychological assessments of other cognitive abilities and electroencephalography (EEG) measures. Additionally, the study will examine the degree to which baseline assessments of cognition and concussion history predict responses to treatment over time, both on assessments administered within the intervention period and at follow-up.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
º Diagnosed with relapsing-remitting multiple sclerosis (RRMS)
º Memory retrieval deficit based on neuropsychological testing done in our lab
º Must be fluent in speaking and reading English.
Exclusion Criteria:
º Relapse or acute MS exacerbation or a course of steroids in t…
Inclusion Criteria:
º Diagnosed with relapsing-remitting multiple sclerosis (RRMS)
º Memory retrieval deficit based on neuropsychological testing done in our lab
º Must be fluent in speaking and reading English.
Exclusion Criteria:
º Relapse or acute MS exacerbation or a course of steroids in the two months preceding the testing
º Participants using benzodiazepines must have been on a stable dose for at least two months
º Potentially confounding psychological or neurological disorder, including:
* dementia of any type
* epilepsy or other seizure disorders
* severe traumatic brain injury
* brain tumor
* present drug abuse
* stroke
* blood vessel abnormalities in the brain
* Parkinson's disease
* Huntington's disease
º inability to give informed consent
º cranial implants
º skull defects that affect tDCS administration
º use of medications that interact with or potentially interact with tDCS effects, including:
* anti-convulsants
* L-dopa
* carbamazepine
* sulpiride
* pergolide
* lorazepam
* rivastigmine
* dextromethorphan
* D-cycloserine
* flunarizine
* ropinirole
* stimulants (dextroamphetamine/amphetamine/modafinil/armodafinil) must be stopped during enrollment
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