No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 – 85
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
40 (estimated)
Sponsor
Medical College of Wisconsin · Other
Who this trial is looking for
This trial is looking for adults who have had a stroke at least 6 months ago. Participants will help researchers understand how blood flow affects muscle fatigue during exercise and try a simple non-invasive treatment to improve blood flow.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 18 and 85 years of age.
I can give informed consent.
I had a stroke at least 6 months ago.
I speak English.
You may not be able to join if
I have a history of blood clots in my legs.
I have a condition that prevents leg compression.
I have chronic pain syndrome.
I have back or hip pain affecting my legs.
I have had head trauma.
I have another neurological disorder.
I have peripheral vascular disease.
I had a heart attack in the past year.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking. This study will examine how blood flow is regulated to the exercising leg muscle post-stroke, because if the muscle does not receive enough blood flow it will become fatigued. Finally, the investigators will use…
The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking. This study will examine how blood flow is regulated to the exercising leg muscle post-stroke, because if the muscle does not receive enough blood flow it will become fatigued. Finally, the investigators will use a safe and simple non-invasive intervention called ischemic conditioning, which has known effects to improve blood flow to exercising muscle and determine the effects on muscle fatigue.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Be between 18-85 years of age
* Able to give informed consent
* ≥6 months post diagnosis of unilateral cortical or sub-cortical stroke
* English speaking
Exclusion Criteria:
* History of blood clots in the extremities or any condition in which compression of the thigh or tra…
Inclusion Criteria:
* Be between 18-85 years of age
* Able to give informed consent
* ≥6 months post diagnosis of unilateral cortical or sub-cortical stroke
* English speaking
Exclusion Criteria:
* History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. wounds in the leg)
* Chronic pain syndrome
* Low back or hip pain that interferes with lower extremity motor testing
* History of head trauma
* Comorbid neurological disorder
* Peripheral vascular disease
* Myocardial infarction in the previous year
* Inability to follow 2 step commands
* Condition where fatiguing contractions or resisted leg contractions are contraindicated
* Resting SBP ≥160 mmHg or DBP ≥ 110 mmHg
* Pregnancy or breastfeeding.
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