No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 65
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
50 (estimated)
Sponsor
Lindsay Maguire, MD · Other
Who this trial is looking for
This trial is looking for adults aged 18-65 who are feeling suicidal and need treatment in the emergency department. Participants will receive low-dose ketamine to see if it helps with their suicidal thoughts.
Are You a Good Fit for This Trial?
Rules you outAcute medical condition requiring hospitalization
You may be able to join if
I am between 18 and 65 years old.
I am feeling suicidal.
I need inpatient care for my suicidal thoughts.
I have a Glasgow Coma Score of 15.
I have been accepted for psychiatric stabilization.
You may not be able to join if
I have a current or past history of psychosis.
I have recent symptoms of mania or hypomania.
I have a history of ketamine use disorder.
I have had a liver transplant.
I am pregnant or breastfeeding.
I am currently imprisoned or unable to consent.
I have a positive urine drug screen or high alcohol level.
I have high blood pressure or low blood pressure.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
There is currently no readily available pharmacologic intervention for suicidal ideation, a true psychiatric emergency, in the Emergency Department (ED). Investigators aim to trial low-dose, intravenous ketamine, a drug with well-established use in treatment-resistant depression, for patients who present to the ED with suicidal ideation.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Acutely Suicidality ("yes" answer to any of items 4 or 5 on C-SSRS "Suicidal Ideation" category)
* Require inpatient stabilization for SI or actions based on clinical observation and interview
* Are accepted for psychiatric stabilization at the University of Kansas Medical Cen…
Inclusion Criteria:
* Acutely Suicidality ("yes" answer to any of items 4 or 5 on C-SSRS "Suicidal Ideation" category)
* Require inpatient stabilization for SI or actions based on clinical observation and interview
* Are accepted for psychiatric stabilization at the University of Kansas Medical Center's Strawberry Hill campus
* Have a Glasgow Coma Score (GCS) of 15
* Age 18-65
Exclusion Criteria:
* Current or past history of psychosis
* Current or recent (past 4 weeks) symptoms of mania/hypomania as defined by Young Mania Rating Scale (YRMS) score of 12 or greater
* History of ketamine use disorder
* History of liver transplant
* Pregnancy or breastfeeding
* Imprisonment or inability to consent
* Positive urine drug screen or serum alcohol level
* Hypertension (SBP \> 160 or DBP \> 100 before administration of ketamine)
* Hypotension (SBP \< 90)
* Presence of acute medical condition requiring admission to medical service
* Allergy, intolerance, or previous adverse reaction to ketamine
* Patient has 8+ lifetime ketamine exposures
* The treating physician determines that the patient is not a good candidate for the study (e.g. medical condition/procedure, medication that would contradindicate ketamine treatment)
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