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At a Glance
Age
18 – 85
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
120 (estimated)
Sponsor
University of Pennsylvania · Other
Who this trial is looking for
This trial is looking for people who have language problems after a stroke. Participants will receive a specific kind of brain stimulation and take language tests to see if it helps improve their language skills.
Are You a Good Fit for This Trial?
You may be able to join if
I have language problems after a stroke.
I had a stroke in the left side of my brain.
My stroke happened at least 6 months ago.
You may not be able to join if
I cannot understand the study.
I have major difficulties naming things.
I have significant hearing loss.
I have a medical history that includes major neurological issues.
I am currently abusing drugs or alcohol.
I am pregnant or plan to become pregnant.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The goal of this study is to see if transcranial alternating current stimulation (tACS) can be used to enhance language abilities in people with post-stroke aphasia. Participants will receive real and sham tACS in conjunction with various language tests. Researchers will compare the post-stroke aphasia group with aged matched controls to see if brain response to tACS differs between groups.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria for Persons with Aphasia:
1. Presence of aphasia
2. Suffered a single, left hemisphere stroke
3. Stroke ≥6 months old (chronic) at the time of enrollment
Inclusion Criteria for Healthy Controls:
1. Right-handedness
2. Must be able to understand the nature of the study, and give…
Inclusion Criteria for Persons with Aphasia:
1. Presence of aphasia
2. Suffered a single, left hemisphere stroke
3. Stroke ≥6 months old (chronic) at the time of enrollment
Inclusion Criteria for Healthy Controls:
1. Right-handedness
2. Must be able to understand the nature of the study, and give informed consent
Exclusion criteria for Persons with Aphasia:
1. Inability to understand the nature of the study
2. Marked naming impairment
3. Impaired non-verbal, conceptual processing
4. History of significant medical or neurological disorder (other than stroke)
5. History of significant or poorly controlled psychiatric disorders
6. Current abuse of alcohol or drugs, prescription or otherwise
7. Nursing a child, pregnancy, or intent to become pregnant during the study
8. Clinically significant hearing loss
9. Contraindications to tACS
10. Contraindications to MRI
Exclusion Criteria for Healthy Controls
1. Diagnosis of a neurodegenerative disease or clinically significant cognitive complaint
2. Any unrelated neurologic or physical condition that impairs communication ability
3. History of unrelated neurological conditions including but not limited to traumatic brain injury, stroke, or small vessel disease that has resulted in a neurologic deficit
4. Any additional neurological condition that would likely reduce the safety of study participation, including central nervous system (CNS) vasculitis, intracranial tumor, intracranial aneurysm, multiple sclerosis or arteriovenous malformations
5. A medically unstable cardiopulmonary or metabolic disorder
6. Terminal illness associated with survival \<12 months
7. Major active psychiatric illness that may interfere with required study procedures or treatments as determined by the enrolling physician
8. Current abuse of alcohol or drugs, prescription or otherwise
9. Contraindications to tACS
10. Contraindications to MRI
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