PATH Therapy for PTSD and Depression
Positive Processes and Transition to Health (PATH)
Recruiting
N/A
Interventional Study
Posttraumatic Stress Disorder
Major Depressive Disorder
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 65
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 135 (estimated)
- Sponsor
- Case Western Reserve University · Other
Who this trial is looking for
This trial is looking for people who have experienced a significant life event that caused trauma or loss and may be dealing with ongoing symptoms of PTSD or depression. Participants will receive six sessions of either the PATH therapy or Progressive Muscle Relaxation therapy.
Are You a Good Fit for This Trial?
You may be able to join if
- I have experienced a destabilizing life event involving profound loss or threat in the last 5 years.
- At least 12 weeks have passed since the event.
- I am between 18 and 65 years old.
- I have moderate or higher symptoms related to re-experiencing the event, avoidance, or lack of reward.
You may not be able to join if
- I have a current diagnosis of schizophrenia or similar disorders.
- I have a current diagnosis of bipolar disorder or severe depression requiring immediate treatment.
- I have attempted suicide or engaged in severe self-injurious behavior in the past three months.
- I am currently in cognitive behavioral psychotherapy and cannot discontinue it.
- I have no clear memory of the traumatic event or it happened before I was 3 years old.
- I have had unstable doses of psychotropic medications in the past 3 months.
- I am in an ongoing relationship with someone who caused the event.
- I have a current diagnosis of a substance use disorder.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
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About This Trial
The R33 will be a randomized controlled trial to replicate changes in the targets (unproductive processing, avoidance, reward deficits) from the R61 phase in a larger sample of 135 participants who have experienced a destabilizing life event involving profound loss or threat, report persistent stressor-related symptoms of PTSD and/or depression, and are elevated on symptoms related to 2 of the 3 t…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Destabilizing life event involving profound loss or threat, with a minimum duration of 12 weeks since the event, but occurred within the last 5 years.
* Between the ages of 18 and 65.
* Elevated target: Scores of at least moderate (1 or higher) on at least 2 of the 3 target me…
Contacts