Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
Recruiting
N/A
Interventional Study
Obesity
Insulin Sensitivity
Muscle Weakness
Adiposity
Insulin Resistance
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 70
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 70 (estimated)
- Sponsor
- University of Colorado, Denver · Other
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About This Trial
The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. The main question it aims to answer is how inflammatory molecules secreted by IMAT promote muscle insulin resistance and inflammation, and how these same molecules are diminished after weight loss. Following screening visits involving…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Generally healthy men and women aged 18-70
* BMI between 30-40
* Less than 1 hour of exercise per week
* Women:
1. may be pre or post menopausal
Exclusion Criteria:
* Type 1 or Type 2 diabetes
* Thyroid disease
* History of lung disease
* Active use of nicotine
* Severe p…
Contacts