Weight Loss Effects on Muscle Health in Obesity
Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
Recruiting
N/A
Interventional Study
Obesity
Insulin Sensitivity
Muscle Weakness
Adiposity
Insulin Resistance
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 70
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 70 (estimated)
- Sponsor
- University of Colorado, Denver · Other
Who this trial is looking for
This trial is looking for adults aged 18-70 who are overweight and do little to no exercise. Participants will follow a 12-week weight loss diet and undergo various health tests before and after the program.
Are You a Good Fit for This Trial?
You may be able to join if
- I am generally healthy
- I am between 18 and 70 years old
- I have a BMI between 30 and 40
- I exercise less than 1 hour per week
You may not be able to join if
- I have type 1 or type 2 diabetes
- I have thyroid disease
- I have a history of lung disease
- I currently use nicotine
- I have severe plasma lipid disorders
- I take hormone replacement drugs
- I am currently going through menopause
- I am pregnant or breastfeeding
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. The main question it aims to answer is how inflammatory molecules secreted by IMAT promote muscle insulin resistance and inflammation, and how these same molecules are diminished after weight loss. Following screening visits involving…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Generally healthy men and women aged 18-70
* BMI between 30-40
* Less than 1 hour of exercise per week
* Women:
1. may be pre or post menopausal
Exclusion Criteria:
* Type 1 or Type 2 diabetes
* Thyroid disease
* History of lung disease
* Active use of nicotine
* Severe p…
Contacts