Stimulation for Depression with Anhedonia

Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression

Recruiting N/A Interventional Study
Major Depressive Disorder Anhedonia
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 65
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
72 (estimated)
Sponsor
Florida State University · Other
Who this trial is looking for

This trial is looking for adults aged 18 to 65 who have major depressive disorder and experience a lack of pleasure. Participants will undergo five days of stimulation to help explore how it affects their behavior and mood.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am between the ages of 18 and 65
  • I can provide informed consent
  • I have normal vision or corrected vision
  • I speak and understand English
  • I have been diagnosed with major depressive disorder
  • I have a Patient Health Questionnaire score of 8 or higher
  • I have a Snaith Hamilton Pleasure Scale score greater than 33
  • I have mild suicide risk as per assessment

You may not be able to join if

  • I have ADHD and am currently receiving treatment
  • I have a history of neurological disorders like epilepsy or stroke
  • I have had brain surgery in the past
  • I have a current severe substance use disorder
  • I am pregnant
  • I have claustrophobia
  • I have metal in my body that is ferrous
  • I have had a severe substance use or alcohol use disorder in the last 12 months

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.

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About This Trial
Anhedonia, the inability to seek-out and experience pleasure, is a common symptom in depression that predicts treatment-resistance and is sometimes exacerbated by first-line antidepressants. In our previous research, we found that anhedonia decreases goal-directed behavior and its related neural activity. In this study, we will investigate target engagement from five-consecutive days of stimulatio…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Between the ages of 18 and 65 * Able to provide informed consent * Have normal to corrected vision * Willing to comply with all study procedures and be available for the duration of the study * Speak and understand English * Mild suicide risk as determined by the Hamilton Depr…
Contacts

Justin M Riddle, PhD

850-645-2389

jriddle@fsu.edu

CONTACT