No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 65
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
72 (estimated)
Sponsor
Florida State University · Other
Who this trial is looking for
This trial is looking for adults aged 18 to 65 who have major depressive disorder and experience a lack of pleasure. Participants will undergo five days of stimulation to help explore how it affects their behavior and mood.
Are You a Good Fit for This Trial?
You may be able to join if
I am between the ages of 18 and 65
I can provide informed consent
I have normal vision or corrected vision
I speak and understand English
I have been diagnosed with major depressive disorder
I have a Patient Health Questionnaire score of 8 or higher
I have a Snaith Hamilton Pleasure Scale score greater than 33
I have mild suicide risk as per assessment
You may not be able to join if
I have ADHD and am currently receiving treatment
I have a history of neurological disorders like epilepsy or stroke
I have had brain surgery in the past
I have a current severe substance use disorder
I am pregnant
I have claustrophobia
I have metal in my body that is ferrous
I have had a severe substance use or alcohol use disorder in the last 12 months
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Anhedonia, the inability to seek-out and experience pleasure, is a common symptom in depression that predicts treatment-resistance and is sometimes exacerbated by first-line antidepressants. In our previous research, we found that anhedonia decreases goal-directed behavior and its related neural activity. In this study, we will investigate target engagement from five-consecutive days of stimulatio…
Anhedonia, the inability to seek-out and experience pleasure, is a common symptom in depression that predicts treatment-resistance and is sometimes exacerbated by first-line antidepressants. In our previous research, we found that anhedonia decreases goal-directed behavior and its related neural activity. In this study, we will investigate target engagement from five-consecutive days of stimulation for participants that are within a unipolar major depressive episode and also have high symptoms of anhedonia.
Trial Locations
Loading…
Loading trial locations…
Facility
City
State
Country
Status
Eligibility Criteria
Inclusion Criteria:
* Between the ages of 18 and 65
* Able to provide informed consent
* Have normal to corrected vision
* Willing to comply with all study procedures and be available for the duration of the study
* Speak and understand English
* Mild suicide risk as determined by the Hamilton Depr…
Inclusion Criteria:
* Between the ages of 18 and 65
* Able to provide informed consent
* Have normal to corrected vision
* Willing to comply with all study procedures and be available for the duration of the study
* Speak and understand English
* Mild suicide risk as determined by the Hamilton Depression Rating Scale (HAM-D; less than 3 for the suicidality item) and non-existent or mild risk according to the Depression Symptom Index Suicidality Subscale (DSI-SS).
* Patient Health Questionnaire (PHQ-8) greater than or equal to 8 prior to the first session
* Snaith Hamilton Pleasure Scale (SHAPS) greater than 33 at the first session
* A diagnosis of major depressive disorder on the Mini International Neuropsychiatric Interview for the DSM-V (MINI)
Exclusion Criteria:
* ADHD (currently under treatment)
* Neurological disorders and conditions including, but not limited to history of epilepsy; seizures, except childhood febrile seizures; dementia; history of stroke; Parkinson's disease, multiple sclerosis, cerebral aneurysm; brain tumors
* Medical or neurological illness or treatment for a medical disorder that could interfere with study participation. For example, unstable cardiac disease, HIV/AIDS, malignancy, liver or renal impairment
* Prior brain surgery
* Any brain devices/implants including cochlear implants and aneurysm clips, cardiac pacemaker, or any other implanted electronic device
* History of current traumatic brain injury
* Pregnancy (for females)
* Current severe substance use disorder
* Claustrophobia
* Based on the use of MRI, additional exclusion/inclusion criteria are considered. Note that many contraindications for stimulation are common with MRI and thus are not repeated. Participants must not have metal in the body that is ferrous, will be required to remove all jewelry, must not have tattoos on the face or neck, must refrain from wearing metal in clothing (underwire) or active gear (possibility of metallic microparticle technology), must not be a metal worker or have an eye injury involving metal.
* Anything that in the opinion of the investigator would place the participant at increased risk or preclude the participant's full compliance with or completion of the study
* DSM-V diagnosis of present moderate or severe substance use disorder or alcohol use disorder, and past severe substance use disorder or alcohol use disorder, or psychotic disorder within the last 12 months
Picking one helps us show the most relevant trials first.
Your results are loading in the background — you can
change this any time from the results page.
Set your location to continue
Find My Trials uses your location to surface clinical trials near you.
Add your city or zip code to your profile and try again.