No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
152 (estimated)
Sponsor
VA Office of Research and Development · Federal
Who this trial is looking for
This trial is looking for Veterans with mild to moderate depression. Participants will use an online program called Deprexis to help improve their mood and daily functioning over eight weeks.
Are You a Good Fit for This Trial?
You may be able to join if
I am a Veteran
I can understand and sign the consent form
I have access to the internet and a device like a computer or smartphone
I have mild to moderate depression
I am stable on my psychiatric medications
You may not be able to join if
I have positive symptoms of a psychotic disorder
I have Bipolar I Disorder
I have current suicidal thoughts
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Depressive symptoms are common among Veterans and associated with significant impairment. Timely intervention has the potential to improve mental health outcomes and restore functioning. Interventions delivered through the internet can be completed remotely at any time, and thus minimize burden on Veterans, however the research examining their utility in Veterans is limited. This proposed project …
Depressive symptoms are common among Veterans and associated with significant impairment. Timely intervention has the potential to improve mental health outcomes and restore functioning. Interventions delivered through the internet can be completed remotely at any time, and thus minimize burden on Veterans, however the research examining their utility in Veterans is limited. This proposed project will examine Deprexis, a self-guided internet-delivered intervention, which targets depressive symptoms and associated functional impairments. Interviews will be conducted to gain insight into Veterans' perceptions, needs, and preferences vis-a-vis Deprexis, with results informing a randomized controlled trial. Here an 8-week course of Deprexis will be compared to a treatment-as-usual (TAU) control condition to establish if Deprexis is acceptable and effective for Veterans with mild to moderate depressive symptoms. Veterans engaged in Deprexis are hypothesized to show improvements on measures of functioning and decreases in depressive symptoms compared to the TAU control group. The proposed work has great clinical utility, as it could provide a readily accessible, high-quality intervention for the many Veterans suffering from depressive symptoms, with the potential to improve functioning and long-term outcomes.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
Potential participants include male and female Veterans of all races/ethnicities who are:
* able to comprehend and sign the informed consent form
* have reliable access to the internet and a computer, tablet and/or smartphone
* exhibit mild or moderate, but not very severe, lev…
Inclusion Criteria:
Potential participants include male and female Veterans of all races/ethnicities who are:
* able to comprehend and sign the informed consent form
* have reliable access to the internet and a computer, tablet and/or smartphone
* exhibit mild or moderate, but not very severe, levels of depression
* stable on psychotropic medications
Exclusion Criteria:
Aim 1 and Aim 2: Veterans will be excluded from study participation if they:
* endorse any positive symptoms of a psychotic disorder
* screen positive for Bipolar I Disorder
* report current suicidal risk
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