No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 65
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
162 (estimated)
Sponsor
Barry Sandler · Other
Who this trial is looking for
This trial is looking for adults aged 18-65 who have feelings of depression or are mentally healthy. Participants will receive a heat treatment and possibly a cold water plunge, with follow-up assessments after the treatment.
Are You a Good Fit for This Trial?
You may be able to join if
I am aged between 18 and 65.
I have depression or I am mentally healthy.
I speak English or Spanish.
I can attend all trial visits and complete evaluations.
You may not be able to join if
I have had a bad reaction to heat or cold treatments before.
I take medication that affects my body's temperature control.
I am pregnant or breastfeeding, or plan to become pregnant during the study.
I have had thoughts of suicide or attempted suicide in the past 6 months.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study will recruit 112 medically healthy adults (aged 18-65) currently experiencing depressive symptoms to be randomized to receive either a single Whole Body Hyperthermia (heat therapy) treatment or a Whole Body Hyperthermia treatment followed by a cold water plunge. Participants will complete a baseline assessment of their depressive symptoms as well as 1-week and 2-week post-treatment foll…
This study will recruit 112 medically healthy adults (aged 18-65) currently experiencing depressive symptoms to be randomized to receive either a single Whole Body Hyperthermia (heat therapy) treatment or a Whole Body Hyperthermia treatment followed by a cold water plunge. Participants will complete a baseline assessment of their depressive symptoms as well as 1-week and 2-week post-treatment followup assessments.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Individuals who currently meet study criteria for depression or individuals who do not currently meet criteria for depression
* English or Spanish speaking (able to provide informed consent and complete questionnaires in one of these languages)
* Able and willing to adhere to …
Inclusion Criteria:
* Individuals who currently meet study criteria for depression or individuals who do not currently meet criteria for depression
* English or Spanish speaking (able to provide informed consent and complete questionnaires in one of these languages)
* Able and willing to adhere to trial requirements, including attending all trial visits, preparatory and follow-up sessions, and completing all trial evaluations.
Exclusion Criteria:
* Previous adverse reaction to hypothermia, hyperthermia and/or infrared exposure
* Use of any medication that may impact thermoregulatory capacity.
* Pregnancy, active lactation, or intention to become pregnant during the study period.
* Endorses current active suicidal ideation with a plan or made a suicide attempt in the prior 6 months.
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