Modulating Escape Using Focused Ultrasound

Inclusion Criteria: * 18-65 y.o. * Meets criteria for an anxiety disorder (Generalized Anxiety Disorder, Panic Disorder, Social Anxiety Disorder, Specific Phobia), posttraumatic stress disorder, obsessive-compulsive disorder, or current adjustment disorder with anxiety * Is currently seeking mental health treatment * Is able to read consent document and provide informed consent. * English is a first or primary fluent language. Exclusion Criteria: * Current alcohol or substance use disorder of more than mild severity (as defined by the Diagnostic and Statistical Manual (DSM)-5 and determined using standardized self-report instruments) * Lifetime diagnosis of psychotic disorder or bipolar mania * Presence of neurological disorder that contraindicates brain stimulation or neurophysiological recording: Seizure disorder * Lifetime history of traumatic brain injury with loss of consciousness * Neurodegenerative disorder (e.g., Alzheimer's Disease, Parkinson's Disease, Frontotemporal Dementia) * Presence of other medical disorder that would make it too uncomfortable to sit or lie still for long recording periods * Presence of standard contraindications for magnetic resonance imaging * Metal in the body * Currently pregnant * Claustrophobia * Significant sensitivity to noise * Medical conditions or treatments that lower seizure threshold * History of severe brain injury * History of seizures/ epilepsy * Currently taking anticholinergic mediation, neuroleptic medication, or sedative/ hypnotic medication Note: selective serotonin re-uptake inhibitors (SSRIs), cholinesterase inhibitors or N-methyl-D-aspartate (NMDA) receptor antagonists are allowed if patient has been on a stable regimen of four weeks prior to enrollment * Currently taking chronic opiate medications or substances * Currently taking naltrexone