Low Fat vs. Low Carb Diets for Overweight People

Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change

Recruiting N/A Interventional Study
Overweight Obesity
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 – 50
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
42 (estimated)
Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · NIH
Who this trial is looking for

This trial is looking for adults aged 19 to 50 who are overweight and want to explore how different diets affect body fat. Participants will follow a low-fat diet for 4 weeks and then switch to a low-carb diet for another 4 weeks, with some tests and visits to a medical center involved.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am 19 to 50 years old
  • I have a body mass index (BMI) of 25 or more
  • I am willing to follow study procedures
  • I have been weight stable for the past 6 months
  • I agree to follow Lifestyle Considerations during the study

You may not be able to join if

  • I have a cardiac pacemaker or other implants that might interfere with tests
  • I do not have enough kitchen space for storing food
  • I have conditions that affect my appetite or immune system
  • I take medications that might change my metabolism
  • I travel frequently for work or unable to stick to a routine
  • I cannot avoid off-study foods or supplements that affect my metabolism
  • I am pregnant or breastfeeding
  • I have a significant dislike of many study foods

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial
Background: In a previous study, participants were lived at the NIH and randomly received either a low-fat or a low-carbohydrate diet for 2 weeks and then switched to the other diet for 2 more weeks. Participants who received the low-carbohydrate diet first lost more body fat at the end of the study than those who received the low-fat diet first. Researchers want to see if they can repeat that re…
Trial Locations
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Eligibility Criteria
* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: 1. Stated willingness to comply with all study procedures and availability for the duration of the study 2. Adults aged 18-50 years 3. Weight stable (\< +/- 5% over pa…
Contacts

Nan Zhai, C.R.N.P.

(301) 827-3324

nan.zhai@nih.gov

CONTACT

Valerie L Darcey

(301) 402-9689

valerie.darcey@nih.gov

CONTACT