Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity
Recruiting
N/A
Interventional Study
Obesity
Nonalcoholic Fatty Liver
Diabetes Type 2
Healthy
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 70
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 60 (estimated)
- Sponsor
- Bettina Mittendorfer · Other
Who this trial is looking for
This trial is looking for adults between 18 and 70 years old who are either lean, have normal obesity, or have some forms of obesity with health issues. They can’t be pregnant, use tobacco, or have serious health problems. It's important that they also have stable weights and aren’t taking certain medications that affect sugar and fat levels in the body.
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About This Trial
The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abnormal obesity and lean individuals.
Both groups will have:
* screening visit
* imaging (body composi…
Trial Locations
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Eligibility Criteria
Inclusion Criteria :
* age: ≥18 but ≤70 years
* not pregnant or breastfeeding
* weight stable and sedentary before enrollment
* no use tobacco products, excessive amounts of alcohol, or dietary supplements, or medications known to or suspected to affect glucose and lipid metabolism (aside from cert…
Contacts