Precision Administration of Anti-thymocyte Globulin With or Without Verapamil

Recruiting Phase 2 Interventional Study
Type 1 Diabetes
Prior Safety Data This treatment has already been tested in at least one earlier human trial.
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At a Glance
Age
6 – 35
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Treatment
Participants needed
60 (estimated)
Sponsor
University of Florida · Other
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About This Trial
T cell directed therapy, anti-thymocyte globulin (ATG), in low doses, has been shown to lower HbA1c and preserve endogenous insulin production (measured by C-peptide) in individuals with recently diagnosed type 1 diabetes (T1D). However, not all individuals who received ATG responded to the therapy (i.e., non-responders). Additionally, use of ATG alone does not address inherent beta cell stress. A…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: 1. Must be \>= 6 years \<= 35 2. Must have a diagnosis of T1D for less than 100 days at randomization 3. Willing to provide Informed Consent or have a parent or legal guardian provide informed consent if the subject is \<18 years of age 4. Positive for at least one islet cell au…
Contacts

Jennifer L Hosford, MPH

352-294-5760

jennifer.hosford@peds.ufl.edu

CONTACT