Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
6 – 35
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Treatment
Participants needed
60 (estimated)
Sponsor
University of Florida · Other
Who this trial is looking for
This trial is looking for young people with type 1 diabetes who have been diagnosed for less than 100 days. Participants will receive a treatment that may help their insulin production and will need to follow specific health management during the study.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 6 and 35 years old.
I have been diagnosed with type 1 diabetes for less than 100 days.
I can give consent or my parent/guardian can provide it for me.
I have at least one islet cell autoantibody.
I have C-peptide levels of 0.2 pmol/ml or higher.
I have not had a live vaccine in the last 6 weeks.
I am willing to receive a killed influenza vaccine before starting.
I can manage my diabetes intensively.
You may not be able to join if
I have a significant immune deficiency.
I have active signs of infection right now.
I am pregnant or breastfeeding.
I use other immunosuppressive medications.
I have a history of HIV, Hepatitis B, or Hepatitis C.
I have significant kidney or liver issues.
I have had a live vaccine in the last 6 weeks.
I have an allergy to ATG or Verapamil.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
T cell directed therapy, anti-thymocyte globulin (ATG), in low doses, has been shown to lower HbA1c and preserve endogenous insulin production (measured by C-peptide) in individuals with recently diagnosed type 1 diabetes (T1D). However, not all individuals who received ATG responded to the therapy (i.e., non-responders). Additionally, use of ATG alone does not address inherent beta cell stress. A…
T cell directed therapy, anti-thymocyte globulin (ATG), in low doses, has been shown to lower HbA1c and preserve endogenous insulin production (measured by C-peptide) in individuals with recently diagnosed type 1 diabetes (T1D). However, not all individuals who received ATG responded to the therapy (i.e., non-responders). Additionally, use of ATG alone does not address inherent beta cell stress. A calcium channel blocker, verapamil, has demonstrated C-peptide preservation in newly diagnosed T1D. Investigators will identify those mostly likely to respond to ATG using an ex vivo predictive biomarker of response to ATG. In addition, Investigators will use sequential therapies to increase efficacy (ATG followed by verapamil) and explore synergistic mechanisms. This will be assessing with in depth immunophenotyping and quantify biomarkers of beta cell stress, cell death, and abnormal prohormone processing. Finally, novel clinical trial endpoints will be assessed for their ability to predict treatment efficacy earlier than the standard endpoint at 1 year.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Must be \>= 6 years \<= 35
2. Must have a diagnosis of T1D for less than 100 days at randomization
3. Willing to provide Informed Consent or have a parent or legal guardian provide informed consent if the subject is \<18 years of age
4. Positive for at least one islet cell au…
Inclusion Criteria:
1. Must be \>= 6 years \<= 35
2. Must have a diagnosis of T1D for less than 100 days at randomization
3. Willing to provide Informed Consent or have a parent or legal guardian provide informed consent if the subject is \<18 years of age
4. Positive for at least one islet cell autoantibody; GAD65A, mIAA, if obtained within 10 days of the onset of insulin therapy, IA-2A, ICA, or ZnT8A
5. Must have stimulated C-peptide levels of 0.2 pmol/ml measured during a mixed meal tolerance test (MMTT) conducted at least 21 days from diagnosis of diabetes. Randomization should occur within one month (37 days) of the MMTT.
6. Subjects who are EBV seronegative at screening must be EBV PCR negative within 30 days of randomization and may not have had signs or symptoms of an EBV compatible illness lasting longer than 7 days within 30 days of randomization
7. Be at least 6 weeks from last live immunization
8. Participants are required to receive killed influenza vaccination at least 2 weeks prior to randomization when vaccine for the current or upcoming flu season is available
9. Be willing to forgo live vaccines during the treatment period and for 3 months following last dose of study drug
10. Be willing to comply with intensive diabetes management
Exclusion Criteria:
1. Be immunodeficient or have clinically significant chronic lymphopenia: (Leukopenia (\< 3,000 leukocytes /μL), neutropenia (\<1,500 neutrophils/μL), lymphopenia (\<800 lymphocytes/μL), or thrombocytopenia (\<100,000 platelets/μL).
2. Have active signs or symptoms of acute infection at the time of randomization
3. Have evidence of prior or current tuberculosis infection as assessed by PPD, interferon gamma release assay or by history
4. Be currently pregnant or lactating, or anticipate getting pregnant within the two year study period
5. Require use of other immunosuppressive agents including chronic use of systemic steroids
6. Have evidence of current or past HIV, Hepatitis B or Hepatitis C infection
7. Have any complicating medical issues or abnormal clinical laboratory results that may interfere with study conduct, or cause increased risk to include pre-existing cardiac disease, COPD, sickle cell disease, neurological, or blood count abnormalities
8. Have a history of malignancies other than skin
9. Evidence of liver dysfunction with AST or ALT greater than 3 times the upper limits of normal
10. Evidence of renal dysfunction with creatinine greater than 1.5 times the upper limit of normal
11. Vaccination with a live virus within the last 6 weeks
12. Current or ongoing use of non-insulin pharmaceuticals that affect glycemic control within prior 7 days of screening
13. Active participation in another T1D treatment study in the previous 30 days
14. Prior treatment with any investigational agent to delay beta cell loss in T1D
15. Known allergy to ATG or Verapamil
16. Prior treatment with ATG, Verapamil or known allergy to rabbit derived products
17. Any condition that in the investigator's opinion may adversely affect study participation or may compromise the study results
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