No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
40 – 90
Sex
Any
Study type
Interventional
Purpose
Other
Participants needed
90 (estimated)
Sponsor
University of Wisconsin, Madison · Other
Who this trial is looking for
This trial is looking for people aged 40-90 who have had a stroke and experience issues with language, known as aphasia. Participants will help researchers understand changes in the brain that can affect recovery from aphasia.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 40 and 90 years old.
I am right-handed.
I speak English well.
I have had a single ischemic stroke.
I have aphasia.
I can understand the study and give my consent.
My stroke occurred within the last year for initial study, or more than a year ago for follow-up.
I am medically stable.
You may not be able to join if
I have a significant medical or neurological disorder other than stroke.
I have a significant psychiatric disorder that is not well controlled.
I currently abuse alcohol or drugs.
I have serious vision or hearing loss that isn't corrected.
I am on treatments other than standard stroke care.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Patients with stroke frequently suffer from aphasia, a disorder of expressive and/or receptive language, that can lead to serious health consequences, including social isolation, depression, reduced quality of life, and increased caregiver burden. Aphasia recovery varies greatly between individuals, and likely relies upon the capacity for neuroplasticity, both at a systems level of reorganized bra…
Patients with stroke frequently suffer from aphasia, a disorder of expressive and/or receptive language, that can lead to serious health consequences, including social isolation, depression, reduced quality of life, and increased caregiver burden. Aphasia recovery varies greatly between individuals, and likely relies upon the capacity for neuroplasticity, both at a systems level of reorganized brain networks and a molecular level of neuronal repair and plasticity. The proposed work will evaluate genetic and neural network biological markers of neuroplasticity associated with variability in aphasia, with a future goal to improve prognostics and identify therapeutic targets to reduce the long-term burdens of aphasia.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Ages 40-90
2. Right-handed (prior to stroke)
3. Proficient English speakers
4. History of a single ischemic stroke in the middle cerebral artery territory that is lateralized to the left or right (Aim 1) cerebral hemisphere.
5. Presence of aphasia (Aims 2-3)
6. Capacity to un…
Inclusion Criteria:
1. Ages 40-90
2. Right-handed (prior to stroke)
3. Proficient English speakers
4. History of a single ischemic stroke in the middle cerebral artery territory that is lateralized to the left or right (Aim 1) cerebral hemisphere.
5. Presence of aphasia (Aims 2-3)
6. Capacity to understand the nature of the study and provide informed consent
7. Acute or subacute stroke at the time of Aim 1 enrollment; Stroke #12 months old (chronic) at the time of Aims 2-3 enrollment
8. Medically stable
Exclusion Criteria:
1. History of significant medical or neurological disorder (other than stroke)
2. History of significant or poorly controlled psychiatric disorders
3. Current abuse of alcohol or drugs, prescription or otherwise
4. Clinically significant and uncorrected vision or hearing loss
5. Anything other than standard of care stroke treatment such as Plavix, aspirin (81-300 mg daily), beta-blockers, diabetes medications or choles- terol-lowering agents, thrombolytics (e.g., tPA), anticoagulation agents such as Heparin, Warfarin/Coumadin
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