Exercise Program for Weight Maintenance after Bariatric Surgery
Exercise, Brain Activity, and Weight Maintenance
Recruiting
N/AInterventional Study
ObesityWeight GainBariatric Surgery CandidateAppetitive Behavior
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 70
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
15 (estimated)
Sponsor
Joslin Diabetes Center · Other
Who this trial is looking for
This trial is looking for people aged 18-70 who have regained weight after having weight-loss surgery. Participants will engage in a specific exercise program and share their weight loss history.
Are You a Good Fit for This Trial?
Must not be takingBeta-blockers
Rules you outType 1 diabetesPeripheral neuropathyActive heart or lung diseaseSevere hypertensionCardiovascular diseaseStroke
You may be able to join if
I am between 18 and 70 years old.
I have a body mass index (BMI) over 19.
I weigh no more than 250 kg.
I have regained more than 10% of my maximum weight lost after bariatric surgery in the past 1 to 5 years.
I am generally healthy and can follow the study rules.
You may not be able to join if
I have type 1 diabetes.
I cannot exercise for any reason.
I am pregnant or breastfeeding.
I have heart or lung disease.
I have severe high blood pressure.
I cannot tolerate MRI procedures.
I have a history of cardiovascular disease or stroke.
I have active treatment for cancer.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
This study aims to explore how HIIT influences brain function, neural and molecular pathways related to weight control, setting the stage for future obesity intervention research.
Trial Locations
Loading…
Loading trial locations…
Facility
City
State
Country
Status
Eligibility Criteria
Inclusion Criteria:
* Age 18-70 years
* Body mass index (BMI) \>19 kg/m2 and body weight\< 250kg
* Participants must have experienced a clinically significant weight regain, defined as over 10% of their maximum weight lost, within 1 to 5 years following their bariatric surgery. They will be asked t…
Inclusion Criteria:
* Age 18-70 years
* Body mass index (BMI) \>19 kg/m2 and body weight\< 250kg
* Participants must have experienced a clinically significant weight regain, defined as over 10% of their maximum weight lost, within 1 to 5 years following their bariatric surgery. They will be asked to self-report their weight loss history. Participants must also provide the operative report from their bariatric surgery for reference.
* In good general health with no conditions that could influence the outcome of the trial, and in the judgment of the investigator is a good candidate for the study based on review of available medical history, physical examination and clinical laboratory evaluations
* Willing to adhere to the protocol requirements for the duration of the study
Exclusion Criteria:
* Type 1 diabetes mellitus
* Peripheral neuropathy with insensate feet
* Recent blood donation within the last 2 months
* Use of beta-blockers
* Current pregnancy or breastfeeding
* Active Heart or lung disease
* Severe hypertension (systolic \>160 mmHg or diastolic \>90 mmHg)
* Inability to exercise for any reason
* Any known contraindication to exercise testing based on current ACSM guidelines
* MRI contraindications, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body
* Known presence of a structural brain lesion (e.g. tumor, cortical infarct)
* Presence of another neurologic disorder, which could impact findings (e.g. multiple sclerosis)
* History of cardiovascular disease, stroke, congestive heart failure
* Active hematological, renal, pulmonary or hepatic disorders
* Active treatment for cancer
* A history of active alcohol or substance abuse
* Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the study protocol
* History of claustrophobia and inability to tolerate an MRI
* Body weight \>250kgr and largest body diameter of 70cm as there is a certain weight and diameter limit of the MRI scanner
* Unwilling or unable to return for study visits, undergo neuropsychological testing and MRI imaging
* Left-handedness
Picking one helps us show the most relevant trials first.
Your results are loading in the background — you can
change this any time from the results page.
Set your location to continue
Find My Trials uses your location to surface clinical trials near you.
Add your city or zip code to your profile and try again.