No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 75
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
68 (estimated)
Sponsor
Johannes Gutenberg University Mainz · Other
Who this trial is looking for
This trial is looking for people with agoraphobia or social phobia. Participants will explore how different therapy methods can help with their anxiety and body awareness.
Are You a Good Fit for This Trial?
Must not be takingMedication affecting the cardiovascular systemCortisoneCorticosteroid creams
You may be able to join if
I have been diagnosed with agoraphobia with or without panic disorder
I have been diagnosed with social phobia
I am a healthy individual without mental illness
I may have a depressive disorder alongside my other diagnosis
You may not be able to join if
I have substance dependence or schizophrenia
I have bipolar disorder or dementia
I have an eating disorder or PTSD
I have a major depressive episode or personality disorder
I have cancer or cardiovascular diseases
I have epilepsy or autoimmune diseases
I am currently pregnant or breastfeeding
I am undergoing psychotherapy
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Anxiety disorders, including agoraphobia, are prevalent in the German population, leading affected individuals to avoid specific places like crowds or public transport. Although cognitive-behavioral therapy with exposure is an effective treatment, many patients resort to medication rather than therapy. Virtual Reality Exposure Therapy (VRET) shows promise in easing exposure treatment with customiz…
Anxiety disorders, including agoraphobia, are prevalent in the German population, leading affected individuals to avoid specific places like crowds or public transport. Although cognitive-behavioral therapy with exposure is an effective treatment, many patients resort to medication rather than therapy. Virtual Reality Exposure Therapy (VRET) shows promise in easing exposure treatment with customizable scenarios. Interoception (body symptom perception) and the endocannabinoid system are explored as factors in maintaining agoraphobia. Studies investigate how therapies like exposure (both in vivo and in VR) impact these factors and treatment outcomes. Interoception, especially in panic disorder patients, plays a crucial role, with accurate heartbeat perception linked to maintaining anxiety. The endocannabinoid system, affecting various functions, is studied for its role in therapy outcomes and its modulation of the body's stress response. The study aims to understand how these systems interact in agoraphobic patients and how therapy affects their functionality.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Experimental group: Diagnosis of agoraphobia with or without panic disorder
* Clinical control group: diagnosis of social phobia
* Control group: healthy individuals without acute or chronic mental illness
* A depressive disorder may be present as a comorbid diagnosis in the e…
Inclusion Criteria:
* Experimental group: Diagnosis of agoraphobia with or without panic disorder
* Clinical control group: diagnosis of social phobia
* Control group: healthy individuals without acute or chronic mental illness
* A depressive disorder may be present as a comorbid diagnosis in the experimental group and the clinical control group
Exclusion Criteria:
* Other mental illnesses: Substance dependence, schizophrenia, bipolar disorder, dementia, eating disorders, PTSD, major depressive episode, personality disorder
* Somatic diseases: Cancer, cardiovascular diseases, epilepsy, autoimmune diseases, metabolic or endocrine diseases
* Taking psychotropic medication (except antidepressants) or medication that affects the cardiovascular system (e.g. beta-blockers), medication containing cortisone, use of creams with corticosteroids
* Pregnancy, breastfeeding
* Ongoing psychotherapy
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