Clemastine for Late-life Depression
Clemastine for Improving White Matter and Boosting Antidepressant Response in Late-life Depression
- Age
- 60 and older
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 80 (estimated)
- Sponsor
- University of Illinois at Chicago · Other
This trial is looking for older adults with depression to see if taking clemastine can improve brain function and enhance the effects of antidepressants. Participants will undergo assessments to confirm eligibility before joining the study.
You may be able to join if
- I am over 60 years old.
- I have been diagnosed with major depressive disorder.
- I have moderate to severe depressive symptoms.
- I am seeking treatment for depression.
- I have a good score on a cognition test.
- I speak English or Spanish.
You may not be able to join if
- I have other major psychiatric disorders.
- I have a history of substance abuse in the last year.
- I have a developmental disorder or low intelligence quotient.
- I have had thoughts of hurting myself in the last month.
- I am experiencing intense grief.
- I have current or past psychosis.
- I have a primary neurological disorder.
- I have an unstable medical condition that needs urgent treatment.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your EligibilityThe goal of this study is to find out if the antihistamine, clemastine, can make the white matter in the brain better in older adults with depression. The study will also determine whether this improvement can make antidepressant treatment work better, reduce depressive symptoms, and improve memory and thinking.
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